Registration Dossier
Registration Dossier
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EC number: 293-671-6 | CAS number: 91081-64-0 Slag produced during ilmenite smelting (ore or sand). Consists primarly of TiO2, FeO, Al2O3, SiO2, MgO and other metal oxides.
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to standard method (ASTM Method E-981); - purity and stability data of test item are missing
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
- Type of study / information:
- acute toxicity
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ASTM Method E-981
- Principles of method if other than guideline:
- respiration rate of the mice after inhalation exposure
- GLP compliance:
- no
Test material
- Reference substance name:
- Titanium dioxide
- EC Number:
- 236-675-5
- EC Name:
- Titanium dioxide
- Cas Number:
- 13463-67-7
- Molecular formula:
- O2Ti
- IUPAC Name:
- dioxotitanium
- Reference substance name:
- Rutile (TiO2)
- EC Number:
- 215-282-2
- EC Name:
- Rutile (TiO2)
- Cas Number:
- 1317-80-2
- IUPAC Name:
- dioxotitanium
- Details on test material:
- - Name of test material (as cited in study report): raw titanium dioxide
- Lot/batch No.: 7C3C/19196
- MMAD: 1.47-1.77 µm
No further details are given.
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
There was a small decrease in respiratory rate (17%) at both exposure concentrations. A meaningful RD50 could not be calculated.
Applicant's summary and conclusion
- Conclusions:
- Raw Titanium dioxide was shown not to be a sensory irritant to mice at the concentrations tested.
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