Registration Dossier
Registration Dossier
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EC number: 233-118-8 | CAS number: 10039-54-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- The reduction of hydroxylamine and some aryl hydroxomates by liver mitochondria from mammals and birds.
- Author:
- Bernheim, M.L.C.
- Year:
- 1 972
- Bibliographic source:
- Enzymologia, 43, 167-176
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In-vitro test system with mitochondrial preparations from various liver sources, warm-blooded animals (mammals and birds) as well as from fish, reptiles, and amphibians. The enzymatic reduction of hydroxylamine and anthranilic hydroxamate with mitochondrial hydroxylamine reductase in the presence of NADH was considered.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydroxylammonium chloride
- EC Number:
- 226-798-2
- EC Name:
- Hydroxylammonium chloride
- Cas Number:
- 5470-11-1
- Molecular formula:
- ClH.H3NO
- IUPAC Name:
- hydroxyammonium chloride
- Details on test material:
- - Name of test material (as cited in study report): hydroxylamine, stored as the hydrochloride
- Stability under test conditions / Storage condition of test material: Hydroxylamine was stored as the hydrochloride at 4°C as a 0.1 M solution, and was stable for many months (it was diluted and neutralized just before use)
Constituent 1
- Radiolabelling:
- no
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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