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EC number: 211-670-0 | CAS number: 683-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study predates GLP and lacks information on exposure conditions and purity of test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Nine male albino rabbits of the New Zealand Strain were incorporated in this study. A dosage of 100 mg of DM-8122 was introduced into the conjunctival sac of the right eye of each rabbit; the left eye served as an untreated control. Three of the rabbit eyes were rinsed with approximately 20 ml of luke warm water two seconds after instillation of the test material, and three of the rabbit eyes were washed similarly four seconds after instillation of the test compound. The remaining three treated eyes were left unwashed.
The nine treated rabbit eyes were scored against the corresponding untreated control eyes according to the method of Draize (Draize, J. H., in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, Assoc. of Food and Drug Officials of U.. S., Austin, Texas, 1956) at 24, 48 and 72 hours after instillation of DM-8122. - GLP compliance:
- no
- Remarks:
- Pre-dates GLP
Test material
- Reference substance name:
- Dibutyltin dichloride
- EC Number:
- 211-670-0
- EC Name:
- Dibutyltin dichloride
- Cas Number:
- 683-18-1
- Molecular formula:
- C8H18Cl2Sn
- IUPAC Name:
- dibutyltin dichloride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data regarding test animals and environmental conditions was reported.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- A dosage of 100 mg of the test material was introduced into the conjunctival sac of the right eye of each rabbit; the left eye served as an untreated control. Three of the rabbit eyes were rinsed with approximately 20 ml of luke-warm water two seconds after instillation of the test material, and three of the rabbit eyes were washed similarly four seconds after instillation of the test compound. The remaining three treated eyes were left unwashed.
- Observation period (in vivo):
- 24, 48 and 72 hour intervals
- Number of animals or in vitro replicates:
- 9 male rabbits (3 for each group)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Three of the rabbit eyes were rinsed with approximately 20 ml of luke-warm water two seconds after instillation of the test material, and three of the rabbit eyes were washed similarly four seconds after instillation of the test compound. The remaining three treated eyes were left unwashed.
SCORING SYSTEM:
Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Draize score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 110
- Reversibility:
- not specified
- Irritant / corrosive response data:
- The group mean score at 24 hours was 110/110. The group mean scores at 48 and 72 hours were 110/110. The Draize evaluation does not provide for the observation of hemorrhage which was noted in this test. The test material would be considered a severe irritant to the eye.
- Other effects:
- One rabbit from each group was selected for autopsy following the 72-hour reading. Complete enucleation of the eye was noted in each animal examined.
Any other information on results incl. tables
Results:
|
No rinse | 2 seconds and rinsed | 4 seconds and rinsed | |||||||
Rabbit 1 | Rabbit 2 | Rabbit 3 | Rabbit 4 | Rabbit 5 | Rabbit 6 | Rabbit 7 | Rabbit 8 | Rabbit 9 | ||
24 hours | Cornea | |||||||||
Opacity | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Area Involved | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Iris | ||||||||||
Evaluation | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
Conjunctivea | ||||||||||
Hyperemia | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
Chemosis | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Discharge | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
Total Score | 110 | 110 | 110 | 110 | 110 | 110 | 110 | 110 | 110 | |
48 hours | Cornea | |||||||||
Opacity | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Area Involved | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Iris | ||||||||||
Evaluation | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
Conjunctivea | ||||||||||
Hyperemia | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
Chemosis | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Discharge | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
Total Score | 110 | 110 | 110 | 110 | 110 | 110 | 110 | 110 | 110 | |
72 hours | Cornea | |||||||||
Opacity | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Area Involved | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Iris | ||||||||||
Evaluation | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
Conjunctivea | ||||||||||
Hyperemia | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
Chemosis | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
Discharge | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
Total Score | 110 | 110 | 110 | 110 | 110 | 110 | 110 | 110 | 110 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Draize method
- Conclusions:
- According to the Draize evaluation, the test material would be considered a severe irritant to the eye.
- Executive summary:
In a primary eye irritation study in rabbits (AME contract number: 120-697-12-70) the test material was considered a severe irritant to the eye.
The scoring was conducted according to the Draize method. The Draize evaluation does not provide for the observation of hemorrhage which was noted in this test.
One rabbit from each group was selected for autopsy following the 72-hour reading. Complete enucleation of the eye was noted in each animal examined.
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