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Diss Factsheets
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EC number: 211-670-0 | CAS number: 683-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The following studies have been submitted to address the toxicity to microorganisms endpoint:
Stasinakis A et al (2001). Toxicity of Organotin Compounds to Activated Sludge. Ecotoxicology and Environmental Safety 49, 275-280.
Steinhaüser K et al (1985). Investigations on the Aquatic Toxicity of Organotin Compounds. Vom Wasser, 65: 203-214.
Stasinakis et al (2001) has been allocated a Klimisch score of 2; Steinhaüser et al (1985) has been allocated a Klimisch score of 4. Stasinakis et al (2001) has been determined to be the key study for this endpoint.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 11.5 mg/L
Additional information
Stasinakis A et al (2001) was allocated as the key study for this data requirement. The study was a short-term screening test conducted to evaluated the toxicity of organotins to activated sludge and the impact of sludge age on the toxicity of these compounds. The study was performed in line with good scientific principles with a good level of reporting as such the study was assigned a reliability score of 2 (reliable with restrictions) and considered adequate for assessment inhibition of respiration rate of activated sludge heterotrophic microorganisms was determined for dibutyltin dichloride (DBTC). The effect of various experimental parameters, such as sludge age, concentrations of suspended solids, and exposure time, on toxicity was investigated. An increase in sludge age or in the concentration of suspended solids reduces the observed inhibition. Longer exposure seems to increase the inhibition during the first hours of exposure, while later the inhibition remains constant. The IC50 was determined for DBT to be 11.5 mg/L (sludge age 10 days) and 35.6 mg/L (sludge age 20 days).
Two studies by Steinhaüser K et al (1985), were assigned reliability scores of 4 (not assignable). The studies were published within the same literature paper, but were performed using different species of bacteria. The firststudy using Photobacterium phosphoreum the reported the test material to have an LC50 value of 217µg/L. (Details of the toxic effects were not reported other than the effects concentration.). The second study used Pseudonomas putida, with which an EC10 value of 2500 µg/L was reported (Details of the toxic effects other than the effects of concentration for this species were also not reported.)
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