Registration Dossier
Registration Dossier
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EC number: 204-727-6 | CAS number: 125-12-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific review (peer reviewed). No data on GLP.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- The maximization test was carried out on 25 volunteers; the material was tested at a concentration of 10% in petrolatum. The author of the study report is Dr. Klingman - coauthor of the maximization test adopted by OECD.
- GLP compliance:
- not specified
- Type of study:
- other: maximization test
- Justification for non-LLNA method:
- LLNA method was not established at time of study
Test material
- Reference substance name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
- EC Number:
- 204-727-6
- EC Name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
- Cas Number:
- 125-12-2
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl acetate
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- 10% in petroleum
Challenge
- Concentration / amount:
- 10% in petroleum
- No. of animals per dose:
- 25 volunteers
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: no data
- Group:
- test chemical
- Dose level:
- No data
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- no data
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: no data
- Group:
- negative control
- Dose level:
- 0
- Clinical observations:
- no data
- Remarks on result:
- not measured/tested
- Reading:
- other: no data
- Group:
- positive control
- Dose level:
- no data
- Clinical observations:
- no data
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
The substance produced no sensitization reactions.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Conclusions:
- The substance was no sensitizing.
- Executive summary:
The maximization test of Isobornyl acetate was carried out on 25 volunteers; the material was tested at a concentration of 10% in petrolatum. The substance produced no sensitization reactions.
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