Registration Dossier
Registration Dossier
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EC number: 204-727-6 | CAS number: 125-12-2
Endpoint summary
Administrative data
Description of key information
Acute toxicity oral: LD50 for rats is greater than 10000 mg/kg bw.
Acute toxicity: dermal: LD50 is 20000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific publication peer reviewed.
- Principles of method if other than guideline:
- LC50 oral (gavage) determined in mouse.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 9 000 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 = 9000 mg/kg bw (mice)
- Executive summary:
The LD50 of isobornyl acetate in mice (gavage) is 9000 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific review (peer reviewed). No data on GLP.
- Principles of method if other than guideline:
- No data on the method.
- GLP compliance:
- not specified
- Test type:
- other: no data
- Species:
- rat
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Oral LD50 (rats) is greater than 10g/kg/bw.
- Executive summary:
The oral LD50 of isobornyl acetate determined in rats is greater than 10g/kg/bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
- Quality of whole database:
- Reliable
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific review (peer reviewed). No data on GLP.
- Principles of method if other than guideline:
- No data provided on the method.
- GLP compliance:
- no
- Test type:
- other: no data
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 20 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 in rabbit is greater than 20000 mg/kg bw
- Executive summary:
The dermal LD50 of Isobornyl acetate for rabbits is greater than 20000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 20 000 mg/kg bw
Additional information
Acute toxicity, oral:
Weight of evidence: The oral LD50 determined in rats is greater than 10000 mg/kg/bw.
Weight of evidence: The LD50 in mice (gavage) is 9000 mg/kg bw.
Acute toxicity, dermal:
Key Study: The dermal LD50 of Isobornyl acetate for rabbits is greater than 20000 mg/kg bw.
Justification for classification or non-classification
Acute toxicity:
Oral: LD50>2000mg/kg bw: non classified
Dermal: LD50>2000mg/kg bw: non classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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