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EC number: 201-158-5
CAS number: 78-92-2
Table 1. Fetal observations after exposure to SBA
* p < 0.05
Groups of 15 to 20 sperm-positive rats were exposed to secondary butanol
at concentrations of 0, 3500, 5000, or 7000 ppm, 7 hours/day, throughout
gestation. No treatment-related malformations were observed at any dose.
Maternal food consumption was reduced in all treatment groups. Maternal
body weights were significantly reduced at the mid- and high-doses only.
Fetal body weights were reduced at the mid- and high-dose level.
Resorptions were increased at the highest concentration and the number
of live fetuses/litter was reduced also at the highest concentration.
The NOAEC for developmental toxicity in this study was 3500 ppm, and the
LOAEL for maternal toxicity was 3500 ppm.
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