Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-158-5
CAS number: 78-92-2
Blood concentrations of 2-butanol and its metabolites 2-butanone, 3H-2B,
and 2,3-BD were measured. Peak blood concentrations of 2-butanol (0.59
mg/ml) were observed within 2 hours of exposure. Blood levels declined
to less than 0.05 mg/ml at 16 hours. As the blood 2-butanol
concentration fell, the metabolite concentrations of 2-butanone, 3H-2B,
and 2,3-BD concentrations rose to maximums at 8, 12, and 18hr,
respectively. The peak concentration of 2-butanone was 0.78 mg/ml, while
that of 2,3-BD was 0.21 mg/ml. 3H-2B reached a peak concentration of
0.04 mg/ml. Total AUC values for 2-butanol, 2-butanone, 3H-2B, and
2,3-BD were 3254 ± 258, 9868 ± 566, 443 ± 93, and 3167 ± 503 mg-hr/l,
Following an oral dose of 2-butanone, blood concentrations of 2-butanone
and its metabolites 2-butanol, 3H-2B, and 2,3-BD were measured. Blood
MEK concentrations of 0.95 mg/ml peaked at 4 hours and declined to less
than 0.07 mg/ml at 18 hours. As the 2-butanone concentration fell, the
end metabolite 2,3-BD rose to a maximum concentration of 0.26 mg/ml at
18 hours. Peak concentrations of 2-butanol and 3H-2B were 0.033 and
0.027 mg/ml, respectively. These were detected at 6 and 8 hr after the
2-butanone administration. Total AUC values for 2-butanone, 2-butanol,
3H-2B, and 2,3-BD were 10,899 ± 824, 414 ± 38, 382 ± 38, and 3863 ± 238
Pharmacokinetic disposition of 2 -butanol and 2 -butanone are identical
following oral exposure. Both substances are rapidly absorbed following
exposure (as shown by rapid increase in blood concentrations following
dosing) and rapidly eliminated in the blood. Both substances are also
metabolized to identical substances with similar AUC values.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again