Registration Dossier
Registration Dossier
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EC number: 236-671-3 | CAS number: 13463-41-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Pyrithione zinc
- EC Number:
- 236-671-3
- EC Name:
- Pyrithione zinc
- Cas Number:
- 13463-41-7
- Molecular formula:
- C10H8N2O2S2Zn
- IUPAC Name:
- Bis [1-hydroxy-2(1H)-pyridinethionato-O,S](T-4)-zinc
- Details on test material:
- Spec ac: 26 uCi.Umol
Purity: 98%
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- other: rat, rabbit, monkey, dog
- Strain:
- other: Sprague Dawley, New Zealand, Rhesus, Beagle
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: rat = 216-234g, dog = 9.3-12.6kg, rabbit = 2.3-2.8kg, monkey = 3.3-3.5kg
Sex: rat + dog = male, rabbit + monkey = female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.1% w/w triethanolamine lauryl sulphate
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Dose: 1 mg/kg bw
- No. of animals per sex per dose / concentration:
- rat: 4
dog: 4
rabbit: 4
monkey: 2(disposition) 3 (metabolite analysis) - Control animals:
- no
- Details on dosing and sampling:
- urine, faeces, CO2, carcass
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- Carcass: 5.9%
- Details on excretion:
- Urine: 75 - 98%
Faeces: 2.6 - 20%
Metabolite characterisation studies
- Details on metabolites:
- 12 urinary metabolites including 2-pyridinethiol-1-oxide-S-glucoside, 2-pyridinethiol-S-glucuronide, 2-pyridinethiol-1-oxide-S-glucuronide
Applicant's summary and conclusion
- Conclusions:
- The pyrithione moiety is extensively absorbed and then rapidly metabolized and eliminated in the urine, primarily as the glucose and/or glucuronic acid conjugate, after oral dosing in rats, dogs, rabbits, and monkeys. The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
