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EC number: 236-671-3 | CAS number: 13463-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 25 mg/kg bw/day
Additional information
The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.
A guideline acute neurotoxicity with ZPT byBarnett (2005)under the U.S. Environmental Protection Agency (1998) Health Effects Test Guidelines; OPPTS 870.6200: Neurotoxicity screening battery, August, 1998.
On the basis of this study, the no-observable-adverse effect-level (NOAEL) of zinc pyrithione following a single dosage via oral gavage is 25 mg/kg. Changes observed at 25 mg/kg in body weights, feed consumption, and in females, motor activity, were minimal and transient.
A literature search in the open literature has revealed additional studies, which have shown that zinc pyrithione causes this neuropathy in both rats and rabbits. However, the hind limb weakness is reversible. In two studies with rats (Ziller 1977, Snyderet al.1977, following consumption of diet containing 250 ppm zinc pyrithione, animals lost this paralytic effect when returned to control diets.
When the Zinc pyrithione was tested in apes, Funato (1992), no signs of hind limb weakness was observed. Also, in repeated dermal toxicity studies,Ulrich (1993),and inhalation studies, Ulrich (1993), with the rat, no evidence of hind limb weakness was observed with any dose used.
Table 5.16: Summary of neurotoxicity
Method |
Results |
Remarks |
Reference |
Oral GavageRat Sprague Dawley.0, 25, 75, & 150 mg/kg Duration: 15 Days
|
LO(A)EL – 75 mg/kg NO(A)EL – 25 mg/kg There were no statistically significant or biologically important differences among the dosage groups for the hindlimb evaluations in the male or female rats. No test substance-related alterations were noted in the central or peripheral nervous system tissues, eyes with retinas and optic nerves, or skeletal muscle.
|
Reliability – 1 Purpose flag Study result type Test material: zinc pyrithione |
Barnett (2005) (unpublished) |
Justification for classification or non-classification
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