(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study with GLP

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

Principles of method if other than guideline:

There is no need to add in this field.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-220-8

EC Name:

-

Cas Number:

5945-33-5

Molecular formula:

C39H34O8P2

IUPAC Name:

(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Details on test material:

75 - 95% (typical 88%, verified by UV/visible spectrum, Infrared (IR) spectrum, Nuclear Magnetic Resonance (NMR), and Mass spectrum.)

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Nothing to add in this field.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

arachis oil

Details on oral exposure:

2000 mg/kg test substance in arachis oil suspension administered by oral (gavage).

Doses:

2000 mg/kg

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

limit test

Statistics:

no data

Results and discussion

Preliminary study:

Nothing to add in this field.

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: Limit test

Mortality:

no effect

Clinical signs:

no effect

Body weight:

All animals showed expected gain in bodyweight.

Gross pathology:

No abnormalities were noted at necropsy.

Other findings:

Nothing to add in this field.

Any other information on results incl. tables

The test chemical was of very low acute oral toxicity in rats.

Mortality: No deaths were recorded.

Clinical observations: No clinical signs of toxicity were noted.

Morphological findings: No abnormalities were noted at necropsy.

Comment: All animals showed expected gain in bodyweight.

LD50: >2 000 mg/kg

Result: The test chemical was of very low acute oral toxicity in rats.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The test material was considered as a nontoxic substance via acute oral toxicity study in rats.

Executive summary:

According to OECD TG 401, the acute oral toxicity was well investigated and the results indicated the test material has very low toxicity in rats. OECD TG 401 was deleted in 2002 due to animal welfare reasons, however, the validity of the results which accomplished under TG 401 should be confirmed.