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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

Principles of method if other than guideline:
no further details
GLP compliance:
no
Test type:
other: acute method, no further details
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
2 weeks
Doses:
630 - 5000 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 851 mg/kg bw
Mortality:
Mortality was observed in animals but no detailed information are given.
Clinical signs:
Marked redness, moderate swelling, and marked necrosis of the skin were observed.
At all doses, rabbits were lethargic. At doses of 630 and 1300 mg/kg, anorexia was observed, and at a dose of 1300 mg/kg, diarrhea was observed.
Gross pathology:
At necropsy at the end of a 2-week observation period, no treatment-related changes were noted.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Based on the LD50 value and in combination with the observed clinical effects in animal, the substance is suggested to be of low dermal acute toxicity.