Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Food Flavourings and Compounds of Related Structure I. Acute Oral toxicity
Author:
P.M. Jennes, E.C. Hagan, Jean M. Taylor, E.L. Cook and O.G. Fitzhugh
Year:
1964
Bibliographic source:
Fd Cosmet. Toxicol. Vol. 2, pp. 327-343. Pergamon Press

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female

Administration / exposure

Route of administration:
other: intubation
Vehicle:
unchanged (no vehicle)
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 1 420 - <= 3 070 mg/kg bw
Based on:
not specified
95% CL:
ca. 2 090
Mortality:
Death Time: 1-3 days
Clinical signs:
Low doses--depression, high doses--coma

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
As LD50>2000mg/kg bw, the substance is not classified under CLP Regulation.