Registration Dossier
Registration Dossier
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EC number: 209-143-5 | CAS number: 556-88-7
Endpoint summary
Administrative data
Description of key information
Nitroguanidine is of low toxicity to water or soil organism. It does not need to be classified for environment.
Additional information
The test substance nitroguanidine is not toxic to aquatic organisms with fish and daphnia acute toxicity (L/EC50) > 100 mg/L, fish long term toxicity (28-day ELS test NOEC with Pimephales promelas) > 100 mg/L, daphnia long term toxicity (reproduction NOEC) of 260 mg/L, and a 5-day algal toxicity (growth EC50) of 2146 mg/L. Nitroguanidine is not toxic to activated sludge microorganisms as the test substance did not influence respiration rates to any extent up to concentrations to 300 mg/L.
Besides test with nitroguanidine, also tests with photolyzed nitroguanidine have been conducted:
Photolyzed nitroguanidine is of higher toxicity than nitroguanidine. The short-term toxicity for fish (96h LC50) and daphnia (48h EC50) is 34.5 mg/L for Fathead minnow (P. promelas) and 24.6 mg/L for Daphnia magna, respectively. Photolysis increased the acute toxicity for D. magna by a factor from over 115.
In a test conducted for long-term toxicity to aquatic invertebrates, photolysis of nitroguanidine resulted in significant mortality (α= 0.05) to the adults occurred at all nominal test concentrations down to 3.6 mg/L. The LOEC and NOEC of photolyzed nitroguanidine for the daphnids, based on the survival of the adults, were 3.6 mg/L and 2.2 mg/L (nominal concentrations), respectively. Photolyzed nitroguanidine was approximately two orders of magnitude more toxic to daphnids than the parent compound under the same test conditions.
The 5-day EC50 in the green algae Raphidocelis subcapitata, formerly known as Selenastrum capricornutum and Pseudokirchneriella subcapitata for photolyzed nitroguanidine is approximately 32.3 mg/L. Photolysis increased the acute toxicity by a factor of 66.4.
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