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Diss Factsheets
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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: summary of the study report is available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Type of study:
- intracutaneous test
- Justification for non-LLNA method:
- Bühler test with Guinea pigs was performed before the LLNA was set as preferred test method.
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- N,N-diethylethanamine
- Details on test material:
- Triethylamine, no further data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals and environmental conditions:
- no sufficient data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- induction = 0.1% solution in 0.75% saline
challenge = not specified
Challengeopen allclose all
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- induction = 0.1% solution in 0.75% saline
challenge = not specified
- No. of animals per dose:
- 20
- Details on study design:
- Groups of 350 to 450 guinea pigs were given the usual cours of 8 intracutaneous injections of 0.1 % solution in 0.75 % saline made up in deionized water. Challenge doses were given 3 weeks after the last sensitizing dose.
- Challenge controls:
- no data
Results and discussion
- Positive control results:
- no data
In vivo (non-LLNA)
Results
- Reading:
- other: not sensitizing
- Group:
- test chemical
- Dose level:
- no data
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no positive responses were noted in 12 survived animals
- Remarks on result:
- other: Reading: other: not sensitizing. Group: test group. Dose level: no data. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no positive responses were noted in 12 survived animals.
Any other information on results incl. tables
"It was obvious that these guinea pigs were not a particularly healthy although the survivors seemed to be in fair condition. We concluded that if these compounds are potential sensitizers they are extremely weak. This statement is made because we know that subnormal animals are often refractory to sensitization".
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: other: conclusion drawn in the study report
- Conclusions:
- No positive sensitisation response after challenge exposure to test substance was noted in all survived animals.
- Executive summary:
Triethylamine was tested in male albino guinea pigs for its sensitization potential. 0.1% solutions of test material in 0.75% saline was administered to 20 test animals by intracutaneous injection 8 times (not specified if once each day). Challenge doses were given 3 weeks after the last sensitizing dose. 8 animals were infected, killed or died on study. No positive sensitization responses were noted in the 12 survived animals. The animals on study were considered to be not entirely healthy. Therefore if the test substance was a sensitizer, such animals would be more refractory to sensitization. The test substance was considered to be not sensitizing by the author of the study report.
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