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Diss Factsheets
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EC number: 231-626-4 | CAS number: 7659-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions No data on test design. Limited data on environmental conditions. No data on tested concentrations.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Standard acute method with one single administration by gavage per animal and per dose level.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl mercaptoacetate
- EC Number:
- 231-626-4
- EC Name:
- 2-ethylhexyl mercaptoacetate
- Cas Number:
- 7659-86-1
- Molecular formula:
- C10H20O2S
- IUPAC Name:
- 2-ethylhexyl 2-sulfanylacetate
- Details on test material:
- - Name of test material (as cited in study report): Thioglykolsäure-2-äthylhexylester
- Analytical purity: technical quality
- Impurities (identity and concentrations): no relevant impurity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: conventional random strain from "Staatlichen Zentralstelle für Versuchstierzucht und -versorgung, Berlin, Lichtenberg."
- Age at study initiation: no data
- Weight at study initiation: between 150 and 180 g
- Fasting period before study: 18 h before study
- Housing:groups of 10 rats
- Diet (e.g. ad libitum): pellets of standard food of K type
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1/10 (v/v)
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: litterature data - Doses:
- No data
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: every week
- Necropsy of survivors performed: yes
- Other examinations performed: body weight increase, necropsy - Statistics:
- Calculation of LD50: Lichtfield and Wilcoxon for the days of application, and Deichmann and Leblanc until the end of deaths due to test substance.
Results and discussion
- Preliminary study:
- No preliminary study
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 303 mg/kg bw
- 95% CL:
- 259 - 355
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 334 mg/kg bw
- 95% CL:
- 250 - 446
- Mortality:
- No details available
- Clinical signs:
- other: No data.
- Gross pathology:
- At necropsy there were no pathological section findings.
- Other findings:
- Additionnal single sublethal doses were tested: 80 mg/kg bw.
At this dose, after 20 hours, no significant damages of the liver or kidneys were observed (relative and absolute organ weight of liver and kidneys, Hexobarbital sleeping time, serum creatinine rate, activity of Serum LAP and Serum aldolase, hemoglobine rate, urine volume, albumine rate in urine, macrosopic observation . At necropsy there were no pathological section findings and body weights were not adversely affected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The resulting LD50 was 303 mg/kg for male and 334 mg/kg for female.
- Executive summary:
In an acute oral rat toxicity studywith EHTG in peanut oil, the LD50 was 303 mg/kg bw (males) and 334 mg/kg bw (females). There were 70 animals assigned to this study. There were no adverse effects seen in any of the rats during the macroscopic examination at necropsy and body weights were not adversely affected. A single sublethal doses of 80 mg EHTG/kg bw produced no significant damage of the liver or kidneys in either sex.
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