Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-470-5 | CAS number: 2440-22-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1957
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- very little detail on test item, laboratory and test design given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test item was applied on five consecutive days on rat and mouse skin.
- GLP compliance:
- no
- Test type:
- other: single dose, given for five consecutive days
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2H-benzotriazol-2-yl)-p-cresol
- EC Number:
- 219-470-5
- EC Name:
- 2-(2H-benzotriazol-2-yl)-p-cresol
- Cas Number:
- 2440-22-4
- Molecular formula:
- C13H11N3O
- IUPAC Name:
- 2-(2H-1,2,3-benzotriazol-2-yl)-4-methylphenol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- G 32169/1 synthesized 3.5.1957
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: 5% arabic gum
- Details on dermal exposure:
- back of animal was shaved. Test item was applied to the same site on five consecutive days
- Duration of exposure:
- 5 days
- Doses:
- reportd as "400 ccm per rat per day"
approximately 2000 mg/kg bw/day - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- 8 days post-treatment observation period.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: for 5 days
- Mortality:
- none
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
