Nonanoic acid

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1969

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1969

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

acute oral toxicity test

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

other: Holtzman

Sex:

male

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

not stated

No. of animals per sex per dose:

no data

Control animals:

not specified

Sex:

male

Dose descriptor:

LD50

Effect level:

> 9 040 mg/kg bw

Conclusions:

Under the conditions of this study the LD50 in rats was >9040 mg/kg bw.

Executive summary:

Male Holtzman rats (number unspecified) were exposed orally to a single dose of the test substance. The LD50 was > 9040 mg/kg bw (Emery Industries, 1969).

Cross-reference 2

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1969

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

acute dermal toxicity test

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Species:

rabbit

Strain:

other: albino (not further specified)

Sex:

not specified

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

not stated

Doses:

maximum dose: 9.04 g, other doses not stated

No. of animals per sex per dose:

no data

Control animals:

not specified

Dose descriptor:

LD50

Effect level:

> 9 040 mg/kg bw

Local irritation of undiluted material: erythema and oedema, followed by  desquamation, coriaceousness, and fissuring of the skin. These effects were more marked in the highest dose group.

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of this study the dermal LD50 was > 9.04 g/kg bw. The single application was irritating to the skin.

Executive summary:

The dermal LD50 in albino rabbits was > 9.04 g/kg bw (no further details). The exposure was irritating to the skin, causing erythema and edema, initially followed by desquamation, coriaceousness and fissuring (Emery Industries, 1969).

Cross-reference 3

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1969

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

testing for irritation/corrosion of the skin

GLP compliance:

not specified

Species:

rabbit

Strain:

other: albino

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Duration of treatment / exposure:

no data

Observation period:

no data

Number of animals:

no data

Irritant / corrosive response data:

Dermal irritation was produced, characterized by erythema and edema initially followed by desquamation, coriaceousness, and fissuring. These signs were more marked in the highest dosage group.

Conclusions:

Data presented in this report are insufficient for a definite interpretation of the results.

Executive summary:

Testing for irritation of the skin in rabbits with the undiluted test item (EMFAC 1202 Pelargonic acid) produced dermal irritation increasing with dosage (Emery, 1969).

Data source

Reference

Reference 1

Reference Type:

other company data

Title:

Unnamed

Year:

1969

Report date:

1969

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1944

Report date:

1944

Materials and methods

Principles of method if other than guideline:

Method: testing for irritation of the eye
Scoring according to Draize et al., 1944

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Nonanoic acid

EC Number:

203-931-2

EC Name:

Nonanoic acid

Cas Number:

112-05-0

Molecular formula:

C9H18O2

IUPAC Name:

nonanoic acid

Details on test material:

- Name of test material (as cited in study report): EMFAC 1202 Pelargonic acid

Test animals / tissue source

Species:

rabbit

Strain:

other: albino

Test system

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

Amount applied: 91 mg

Duration of treatment / exposure:

not stated

Observation period (in vivo):

do data

Number of animals or in vitro replicates:

no data

Details on study design:

Comment: not rinsed

SCORING SYSTEM:
- In this report of Emery (1969) it is stated that the evaluation of the eye injury data was based upon the method of Draize. The authors refer to an unpublished reference of the "Association of Food and Drug Officials of the United States". As the presentation of the results by Emery (1969) is in accordance with the scoring system presented by Draize et al. (1944), it is assumed that this scoring system was the basis for the evaluation of the ocular lesions. The scoring system of Draize et al. (1944) is presented below. The scores are comparable to the scores of the OECD TG 405.
- Readings usually made at 1, 24 and 48 hours after instillation of the agent into the eye as well as after 96 hours if residual injury is present.

Results and discussion

Any other information on results incl. tables

"Marked irritation": iritis, conjunctivitis, corneal opacity. No further  data

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

Data presented in this report are insufficient for a definite interpretation of the results.

Executive summary:

The test item was applied to the eyes of albino rabbits and produced marked irritation, including signs as iritis, conjunctivitis and corneal opacity (Emery, 1969).