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EC number: 222-598-4 | CAS number: 3547-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to OECD 408. Study did not include clinical biochemistry determinations, ophthalmological examination. Some tissues were not examined such as spinal cord, pituitary, thymus, female mammary glands, and peripheral nerves.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- yes
- Remarks:
- See above rationale for reliability
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-(octylthio)ethanol
- EC Number:
- 222-598-4
- EC Name:
- 2-(octylthio)ethanol
- Cas Number:
- 3547-33-9
- Molecular formula:
- C10H22OS
- IUPAC Name:
- 2-(octylsulfanyl)ethan-1-ol
- Reference substance name:
- Ethanol, 2-(octylthio)-
- IUPAC Name:
- Ethanol, 2-(octylthio)-
- Reference substance name:
- 2-hydroxyethyl-n-octyl sulfide
- IUPAC Name:
- 2-hydroxyethyl-n-octyl sulfide
- Details on test material:
- - Name of test material (as cited in study report): Repellent 874
- Name of test material- Repellent 874, Technical Grade, consists of 95 % (based on percent of theoretical sulfur content) or more of 2-hydroxyethyl-n-octyl sulfide and 5 % or less of related compounds-all considered active for labeling purposes by the Environmental Protection Agency.
- Stability under test conditions: Stable under all usual conditions of storage and use. Avoid highly alkaline emulsifiers in emulsion concentrates.
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 21 days
- Weight at study initiation: 40-50 g
- Housing: The animals were housed in screen-bottom individual cages.
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: ground commercial laboratory chow, basal ration
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS:
Test diets were formulated biweekly, or more often as required, and test animals were fed thrice weekly or as required.
DIET PREPARATION
- Rate of preparation of diet (frequency): biweekly or as required.
VEHICLE
- Justification for use and choice of vehicle (if other than water): laboratory diet
- Concentration in vehicle: 0, 0.08, 0.4 and 2.0% - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- Animals were fed thrice weekly, or as required.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.08, 0.4, and 2%
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
74, 368, 1842 mg/kg bw/day
Basis:
other: calculated (see Overall remarks section)
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- No data
Examinations
- Observations and examinations performed and frequency:
- BODY WEIGHT: Yes
- Time schedule for examinations: weekly
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): yes, calculated as average in grams per group of 10 animals on a weekly basis.
HAEMATOLOGY: Yes
- Time schedule for collection of blood: 4 weeks, 8 weeks and 13 weeks
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: 5 animals per sex per group
- Parameters examined: red blood cell count, white blood cell count, hemoglobin, neutrophils, lymphocytes, monocytes, eosinophils and basophils
URINALYSIS: Yes
- Time schedule for collection of urine: 4 weeks, 8 weeks and 13 weeks
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data
- Parameters examined: specific gravity, pH, nitrogen, blood, sugar, and albumin - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes, including organ weight measurements (liver, heart, kidney, spleen and gonads)
HISTOPATHOLOGY: Yes, brain, thyroid, larynx, salivary gland, lymph node, lung, heart, liver, kidney, spleen, pancreas, small intestine, colon, stomach, urinary bladder, testes or ovary, uterus, bone and bone marrow.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- BODY WEIGHT AND WEIGHT GAIN
No significant differences found.
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study)
No significant differences found.
HEMATOLOGY
No significant differences found.
URINALYSIS
No significant differences found.
ORGAN WEIGHTS
No significant differences found.
GROSS PATHOLOGY
No significant differences found.
HISTOPATHOLOGY: NON-NEOPLASTIC
No significant differences found.
HISTOPATHOLOGY: NEOPLASTIC (if applicable)
No significant differences found.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- >= 2 other: %
- Sex:
- male/female
- Basis for effect level:
- other: No observed effects of the test substance present in females or males up to a concentration of 2% of the test substance (top dose evaluated in study).
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No changes related to treatment with test substance were observed. This lead to the conclusion that under these test conditions, the test substance was not toxic to test animals. NOEL >=2 %.
- Executive summary:
In a repeated dose study conducted with methods similar to OECD #408 guidelines, 21-day-old Sprague-Dawley rats (10/sex) were exposed via the diet for 13 weeks to 0, 0.08, 0.4 and 2.0% (estimated to be 74, 368, and 1842 mg/kg/day, respectively) ethanol, 2-(octylthio). The animals were fed 3 times weekly, or as required. Weight and food consumption data were collected weekly. Urinalysis and hematological evaluations were performed at 4, 8 and 13 weeks. Terminal examinations including gross necropsy, organ weight measurements (liver, heart, kidney, spleen and gonads) and histological examination of tissue specimens of the brain, thyroid, larynx, salivary gland, lymph node, lung, heart, liver, kidney, spleen, pancreas, small intestine, colon, stomach, urinary bladder, testes or ovary, uterus, bone and bone marrow were included. No treatment-related effects were observed during the 13-week study or at necropsy for any of the parameters measured; the NOEL was determined to be greater than or equal to 2% (estimated to be 1842 mg/kg/day).
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