Methyl tetrahydro-2-furancarboxylate

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption

Remarks:

adsorption

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Between 25 January and 16 February 1996

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP, guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1996

Report date:

1996

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD Draft Document TGP/94.75

Principles of method if other than guideline:

Chemicals injected onto a cyano column move along it by partitioning between the mobile phase and the stationary phase.

GLP compliance:

yes

Type of method:

HPLC estimation method

Media:

soil

Test material

Test material information

Constituent 1

Reference substance name:

Methyl tetrahydro-2-furancarboxylate

EC Number:

420-670-1

EC Name:

Methyl tetrahydro-2-furancarboxylate

Cas Number:

37443-42-8

Molecular formula:

C6H10O3

IUPAC Name:

methyl oxolane-3-carboxylate

Details on test material:

Identity: Methfat
Chemical name: Methyl tetrahydro-2-furoate
Batch number: 17-5C03 (GLFC No.002)
Expiry: 7 November 1996
Purity: 99.4%
Appearance: Clear liquid
Storage conditions: In darkness at room temperature
Date received: 17 November 1995

Study design

HPLC method

Details on study design: HPLC method:

EQUIPMENT
Analytical balance: Model AT 261, Mettler-Toledo.
HPLC system:
Autosampler: Model 712 WISP, Waters Associates
Pump: Model Model510, Waters Associates
Detector: UV1000, Spectra Physics
Data handling system: Model 1020, PE Nelson
Plotter: Model Diconix 180si, Kodak

HPLC CONDITIONS: Chemicals injected onto a cyano column move along it by partitioning between the mobile phase and the stationary phase.
Column: Apex cyano, 5µ, 25 cm x 4.6 mm id.
Mobile phase: Methanol/water, 40/60 v/v.
Flow rate: 1.0 ml/min.
Pressure: 3500 psi.
Analytical wavelength: 210 nm.
Injection volume: 50 µl
Chart speed: 5 mm/min.
Range: -50 to 200 mV.
Column temperature: 20 °C +/- 0.5 °C

DETERMINATION OF DEAD TIME
The dead time (the average time a solvent molecule needs to pass through the column) was taken as 2.469 minutes, the time of the earliest consistently appearing peak (mean of 2.467 and 2.470). Thiourea (a recommended organic compound for the measurement of the dead time) was used and was found to be slightly retained on the column.

REFERENCE SUBSTANCES
- Identity: fenthion, monolinuron, sulprofos, triadimenol, triazophos and trifluralin.

DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: test A 47.3 µg, test B 47.9 µg

EVALUATION
- Calculation of capacity factors k': k= t-to/to
- Determination of the log Koc value: log Koc= logk-I/S

Results and discussion

Adsorption coefficient

Type:

Koc

Value:

< 60.3

Temp.:

20 °C

Remarks on result:

other: The test substance is likely to be mobile in soils.

Results: HPLC method

Details on results (HPLC method):

- Dead time to = 2.469 min
- Retention times of reference substances used for calibration: ranged from 4.326 to 15.768 min
- Graph of regression line attached
- Average retention data for test substance: 2.868 min and 3.156 min for an impurity

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The soil adsorption coefficient for MeTHFAT has been determined as Koc <60.3 at 20°C.