Registration Dossier
Registration Dossier
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EC number: 205-465-5 | CAS number: 141-17-3
Endpoint summary
Administrative data
Description of key information
Additional information
No experimental studies investigating the bioaccumulation potential ofBis(2-(2-butoxyethoxy)ethyl) adipate (CAS 141-17-3) are available. Therefore, the bioaccumulation factor (BCF) of the substance was estimated using a reliable QSAR model (BCFBAF v3.01). The substance is in the applicability domain of the model indicating that the results are reliable and can be used to assess the bioaccumulation potential of Bis(2-(2-butoxyethoxy)ethyl) adipate. Using the Arnot-Gobas method, including biotransformation (BCFBAF v3.01, Arnot Gobas, upper trophic), a BCF value of 6.33 L/kg was calculated. An exclusion of biotransformation resulted in a higher BCF of 184 L/kg, indicating that extensive metabolism occurs and significantly reduces the bioaccumulation potential in a short period of time. The QSAR estimated biological half-life is 0.00588 days (corresponding to approx. 8 min). For a detailed review on metabolism of the substance, please refer to the toxicokinetics statement in Chapter 7.1 of the technical dossier. Based on the valid QSAR calculation, it can be concluded that Bis(2-(2-butoxyethoxy)ethyl) adipate has a low potential for bioaccumulation. The calculated BCF values, with and without metabolism, are clearly below the trigger value of 2000 L/kg to be classified as bioaccumulative (B-criterion) in the PBT assessment.
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