Registration Dossier
Registration Dossier
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EC number: 617-268-5 | CAS number: 81919-14-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vivo
Link to relevant study records
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
- Species:
- mouse
- Sex:
- male
- Remarks:
- Doses / Concentrations:
300, 600, 800
Basis:
no data - Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Conclusions:
- Interpretation of results (migrated information): negative
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Mutagenic potential was studied by in vitro or in vivo tests. The results of the in vitro studies did not suggest the risk of gene mutation while chromosomal aberrations had been observed, mainly without metabolic activation. Nevertheless, such effects were not confirmed by repeating the test or by in vivo studies.
Justification for selection of genetic toxicity endpoint
In vivo study
Justification for classification or non-classification
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