Registration Dossier
Registration Dossier
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EC number: 248-107-3 | CAS number: 26919-50-6
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study results were published in a peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information was provided to indicate which specific guideline was followed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Triethanolamine
- IUPAC Name:
- Triethanolamine
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
- Test material form:
- not specified
- Details on test material:
- Test Substance: Triethanolamine
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- 1.125 mg/kg per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.125 mg/kg
Basis:
no data
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- The dose had no effect on maternal mortality
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Other effects:
- not specified
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
Details on results (P0)
Effect levels (P0)
- Basis for effect level:
- other: There were no effects on maternal mortality or on the number of viable litters, litter size, or survival and body weight of the pups.
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified Generation not specified (migrated information)
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- no effects observed
- Mortality / viability:
- no mortality observed
- Description (incidence and severity):
- No effect on the number of viable litters, litter size, or survival and body weight of the pups
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- No effect on the number of viable litters, litter size, or survival and body weight of the pups
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
Details on results (F1)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
There were no effects on maternal mortality or on the number of viable litters, litter size, or survival and body weight of the pups.
Applicant's summary and conclusion
- Conclusions:
- There were no effects on maternal mortality or on the number of viable litters, litter size, or survival and body weight of the pups.
- Executive summary:
The reproductive toxicity of the substance was determined via exposure to mice. There were no effects on maternal mortality or on the number of viable litters, litter size, or survival and body weight of the pups.
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