Registration Dossier
Registration Dossier
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EC number: 217-101-2 | CAS number: 1739-84-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dimethylimidazole
- EC Number:
- 217-101-2
- EC Name:
- 1,2-dimethylimidazole
- Cas Number:
- 1739-84-0
- Molecular formula:
- C5H8N2
- IUPAC Name:
- 1,2-dimethyl-1H-imidazole
- Details on test material:
- - Name of test material (as cited in study report): 1,2-Dimethylimidazol
- Physical state: solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 200, 250, 320, 400, 800, 1600 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/10 animals died at 200 mg/kg bw
0/10 animals died at 250 mg/kg bw
7/10 animals died at 320 mg/kg bw
8/10 animals died at 400 mg/kg bw
10/10 animals died at 800 mg/kg bw
10/10 animals died at 1600 mg/kg bw
deaths occured within day 1 - Clinical signs:
- Immediately until a few minutes after the injection, jumping, tremor, flexor, extensor spasms, dyspnea, cyanosis, abdominal or side position, convulsive spasms, convulsions, crying, extremity cramps. Cramp occurred within one hour. The survivors were partly apathetic after 2 hours with convulsive twitches, prone position. In the following days calm demeanor, shaggy coat were observed. After 6-7 days no symptoms were observed.
- Gross pathology:
- Animals dead during study: severe redness around injection site, partial pale livers
Animals sacrificed after study: no findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
