Registration Dossier
Registration Dossier
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EC number: 217-101-2 | CAS number: 1739-84-0
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
No study on toxicity to birds is available.
Key value for chemical safety assessment
Additional information
No studies on the long-term reproductive toxicity to birds are available for the substance.
In Annex X, Section 9.6.1, Column 2 of Regulation (EC) No 1907/2006, it is laid down that any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level. In case of the substance a mammalian dataset is available. Furthermore, ECHA (2017) states in the "Guidance on information requirements and chemical safety assessment Chapter R.7c" (R.7.10.16) that "given that mammalian toxicity is considered in detail for human health protection, the need for additional data for birds must be considered very carefully – new tests are a last resort in the data collection process."
In case of 1,2-dimethylimidazole (CAS 1739-84-0) a mammalian dataset is available.
In addition, based on the low log Kow, significant bioaccumulation in organisms is not to be expected (see IUCLID Ch. 5.3.1). The Substance is also biodegradable based on an enhanced ready biodegradability test passing the test level of 60% CO2/ThCO2 but not meeting the 10-day window (BASF SE, 2012; see IUCLID Ch 5.2.1); therefore, the substance is assessed to be not P/vP. Hence, secondary poisoning is of no concern.
Therefore, and for reasons of animal welfare, long-term or reproductive toxicity tests on birds do not need to be conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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