Registration Dossier
Registration Dossier
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EC number: 611-435-6 | CAS number: 56962-04-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2002
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-bromo-5-chlorophenol
- EC Number:
- 611-435-6
- Cas Number:
- 56962-04-0
- Molecular formula:
- C6H4BrClO
- IUPAC Name:
- 3-bromo-5-chlorophenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Charles River Laboratories, Research Models and Services, Germany GmbH, Sanhofer Weg 7, 97633 Sulzfeld, Germany
Body weight: 177-190 g
Age 52-53 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesame Oil
- Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 6
- Details on study design:
- Duration of experiment: 5 adaptation days; 1 test day; 2 recovery weeks
Frequency of observations: before and immediately, 5, 15, 30, and 60 min as well as 3, 6, and 24 hours after adminsitration
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- none
- Body weight:
- 177-190 g (at start administration)
- Gross pathology:
- No changes were noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the present test conditions, a single oral administration of 2000 mg/kg b.w. to rats did not reaveal any changes. No mortality occured. No clinical signs were observed. All animals gained the expected body weight throughout the whole study period. No changes were noted at necropsy. The LD50 value was ranked exceeding 2000 mg/kg b.w..
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