3-diethylaminophenol

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

ASSESSMENT OF THE ACUTE TOXICITY AND POTENTIAL IRRITANCY OF HAIR DYE CONSTITUENTS

Author:

G. K. LLOYD, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES

Year:

1977

Bibliographic source:

Fd Cosmet. Toxicol. Vol. 15, pp. 607-610, 1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: United States Code of Federal Regulations (Federal Hazardous Substances Act Regulations 16: Section 1500.42, Test for eye irritants)

Principles of method if other than guideline:

Irritation potential of resorcinol was assessed in New Zealand White rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Resorcinol

Cas Number:

Resorcinol

Molecular formula:

C6H6O2

IUPAC Name:

Resorcinol

Constituent 2

Reference substance name:

1,3-Benzenediol

Cas Number:

108-46-3

Molecular formula:

C6H6O2

IUPAC Name:

1,3-Benzenediol

Constituent 3

Reference substance name:

Resorcinol

EC Number:

203-585-2

EC Name:

Resorcinol

Cas Number:

108-46-3

Molecular formula:

C6H6O2

IUPAC Name:

1,3 benzenediol

Details on test material:

- Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

water

Controls:

yes

Amount / concentration applied:

2.5%

Duration of treatment / exposure:

10 seconds

Observation period (in vivo):

72 hrs

Number of animals or in vitro replicates:

3 animals

Details on study design:

The eyes of all the rabbits were irrigated with 50 ml of lukewarm (37°C) water, 10 sec after instillation of the test material

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 72 hrs

Score:

0

Max. score:

3

Reversibility:

not specified

Remarks on result:

other: mild conjunctival inflammation was seen but did not persist for more than 24 hr.

Irritant / corrosive response data:

mild conjunctival inflammation, disappearing within 24 h post-application

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance resorcinol was found to be not irritating to rabbit when applied at concentration of 2.5 % W/V.

Executive summary:

In three NZW rabbits, the application of a 2.5% (w/v) solution of resorcinol into the eyes (rinsing 10 s after application) caused only mild conjunctival inflammation, disappearing within 24 h post-application. This indicates that the substance resorcinol was found to be not irritating to eye of rabbit.