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REACH

3-diethylaminophenol

EC number: 202-090-9 | CAS number: 91-68-9

Life Cycle description
Uses advised against

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The lethal concentration (LC50) value of 3-diethylaminophenol in fish (Oryzias latipes) in a 48 hr study on the basis of mortality effect was estimated to be 34.03607mg/L. But the BCF value of 3-diethylaminophenol reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering theCLP Criteria for aquatic classification of the substance , it is concluded that 3-diethyl amino phenol does not exhibits short term toxicity to fish (Oryzias latipes)

Key value for chemical safety assessment

Fresh water fish

Effect concentration:: 34.036 mg/L

Additional information

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 91-68-9 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	34.03607mg/l	mortality	48 hrs	Oryzias latipes	Predicted data for target chemical
2	LC50	32.13076mg/l	mortality	48hrs	Pimephales promelas	Predicted data for target chemical
3	LC50	24.43437 mg/l	mortality	96 hrs	Oncorhynchus mykiss	Predicted data for target chemical
4	LC50	17.07mg/l	mortality	96 hrs	Pimephales promelas	Predicted data for target chemical
5	LC50	56.5 mg/l 72.6 mg/l 88.6 mg/l	mortality	96 hrs 48 hrs 24 hrs	Pimephales promelas	Data from publication for CAS NO 108-46-3
6	LC50	60 mg/l	mortality	96 hrs	Pimephales promelas	Data from publication for CAS NO 108-46-3

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 17.07 to 88.6 mg/l in 96, 48 and 24 hrs on the basis of mortality effect .

But the BCF value of 3-diethylaminophenol reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that 3-diethylaminophenol does not exhibit short term toxicity to fish (Oryzias latipes,Pimephales promelas and Oncorhynchus mykiss)

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