Registration Dossier
Registration Dossier
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EC number: 400-600-6 | CAS number: 71868-10-5 ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- Name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance fulfills the requirements for persistence (P) and toxic (T), but does not meet the requirements for bioaccumulation (B).
The biodegradability of the test substance was investigated in a study according to GLP and OECD guideline 301 B. After 28 days a biodegradation rate < 1% was measured. Therefore, the test substance isnot readily biodegradable according to OECD-criteria and regarded as persistent.
In a bioaccumulation study according to Japanese protocol procedures, individuals of Oryzias latipeswere exposed to two concentrations of the test substance for a period of 56 days. The determined BCFvalues are between 5.3 and 10.1. The results are supported by four different QSAR calculations resultingin BCF values < 120. Ths substance is therefore considered not to be bioaccumulative.
The test substance is classified with toxic for reproduction category category 2 (development)Category 3 (fertility) according to Directive 67/548/EEC and toxic for reproduction category 1B aaccording to Regulation EC No 1272/2008. Therefore, the test substance is regarded as toxic.
Referenceopen allclose all
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