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EC number: - | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Determination of the Abiotic Degradation of FAT 40858/A TE (Hydrolysis as a Function of pH)
Key value for chemical safety assessment
Additional information
In a preliminary test the test item was dissolved in aqueous solutions buffered at pH 4, 7 and 9 and incubated at 50 ± 0.5 °C for maximum of 5 days.
No significant reduction of the test item concentration was observed in the samples incubated at pH 4.
In the incubated samples at pH 7 a significant reduction of the test item concentration was observed.
In the incubated samples at pH 9 the test item degraded rapidly. No test item related signal could be found in the freshly prepared samples.
A main test was performed to determine the half-life time of FAT 40858/A TE at pH 7. No main test was performed at pH 4 and pH 9.
Amain test was performed in buffered solutions at pH 7. The test item was dissolved and incubated at 23°C, 40 °C and 50 °C.The concentration of the test item was determined as a function of time. The logarithms of the concentration relation (co/ct) were plotted against the time. A pseudo first order reaction was assumed. The correlation coefficients were calculated and the reaction constants and half lifes were calculated from regression data at each temperature.
For reaction at pH 7 the Arrhenius relationship was
calculated based on data generated at 23, 40 and 50 °C. Logarithm of the
rate constants were plotted against the reciprocal of the absolute
temperature.
Following relation was found:
pH 7: ln k = - 11866 * 1/T + 36
Degradation Products: The UV-chromatograms showed several degradation products as signal eluting prior to the test item signal. In agreement with the sponsor, no identification of the metabolites was performed.
Conclusion:
The test item is stable at pH 4.
At pH 7, the test item is degraded by hydrolysis. The half life of reaction at 23 °C was determined to be 23 h at pH 7.
At pH 9 the test item is supposed to degrade immediately.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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