Registration Dossier
Registration Dossier
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EC number: 208-797-9 | CAS number: 542-05-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: details not available
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : MA3740000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glutaric acid
- EC Number:
- 203-817-2
- EC Name:
- Glutaric acid
- Cas Number:
- 110-94-1
- IUPAC Name:
- glutaric acid
- Details on test material:
- - Name of test material : glutaric acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: Dose data : 0.5 gm ; Reaction Severity : Mild
Applicant's summary and conclusion
- Interpretation of results:
- other: Mild irritation
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Skin irritation of glutaric acid in rabbit was examined at dose concentration of 0.5 gm and showed mild irritation potential.
- Executive summary:
Skin irritation of glutaric acid in rabbit was examined at dose concentration of 0.5 gm and showed mild irritation potential.
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