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EC number: 202-046-9 | CAS number: 91-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May - August 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
- Reference Type:
- publication
- Title:
- Single administration toxicokinetic studies of decalin (decahydronaphthalene) in rats and mice
- Author:
- Dill JA, Fuciarelli AF, Lee KM, Mellinger KM, Chan PC, Burka LT and Roycroft JH
- Year:
- 2 003
- Bibliographic source:
- Toxicol. Sci. 72, 210-222
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- NTP method detailed in the report
- GLP compliance:
- yes
Test material
- Reference substance name:
- Decahydronaphthalene
- EC Number:
- 202-046-9
- EC Name:
- Decahydronaphthalene
- Cas Number:
- 91-17-8
- Molecular formula:
- C10H18
- IUPAC Name:
- decahydronaphthalene
- Reference substance name:
- Dekalin
- IUPAC Name:
- Dekalin
- Details on test material:
- Decalin
Purity >99%
Supplier: Sigma Aldrich Fluka Bulk Chemicals (St Louis, USA)
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- other: rat and mice
- Strain:
- other: F344/N rats and B6C3F1 mice.
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- single 6-hour whole body inhalation exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25, 100, or 400 ppm
- Control animals:
- no
- Positive control reference chemical:
- no positive control
- Details on dosing and sampling:
- Heparinized blood was collected from the retroorbital plexus (rats) or supraorbital sinus (mice) under 70% carbon
dioxide (in room air) anesthesia after exposure. Each animal was bled twice, once in each eye (except rats, which
were sampled three times at less than 5 minutes after exposure, 60 minutes, and approximately 1440 minutes after
exposure). Rats from all exposure groups were bled at 5 minutes or less and at 10, 20, 30, 60, 120, 240, 480, and
1440 minutes postexposure. Mice from the 25 ppm group were bled at 5 minutes or less and at 10, 20, 40, 60, 120,
240, and 360 minutes postexposure. Mice from the 100 and 400 ppm groups were bled at less than 5 minutes and
at 10, 20, 40, 60, 180, 360, and 480 minutes postexposure. Samples were stored at –70° C until analyses.
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Test no.:
- #1
- Toxicokinetic parameters:
- half-life 1st: 23.0-26.6 min
- Test no.:
- #1
- Toxicokinetic parameters:
- half-life 2nd: 418-511 min
- Test no.:
- #1
- Toxicokinetic parameters:
- AUC: 2.18-5.26 µg min/g ppm
Any other information on results incl. tables
Decalin exhibited biexponential blood elimination kinetics in rats and mice after a single 6-hour whole body inhalation exposure. A rapid initial phase (") representing elimination from blood and rapidly perfused tissues such as liver, lung, and kidney was followed by a slower phase ($) representing elimination from slowly perfused tissues such as muscle and fat. The biexponential curves, weighted using [mean decalin blood concentrations]–2, that were used to model the data and to estimate toxicokinetic parameters for rats are presented in Figures M1 and M2; parameter estimates, A0, ", B0, and $, were obtained from these models. The biexponential curves, weighted using [mean decalin blood concentration]–1, that were used to model the data and to estimate toxicokinetic parameters for mice are presented in Figures M2 and M3; parameter estimates, A0, ", B0, and $, were obtained from these models . The parameter estimates, A0, ", B0, and $ were used to calculate t½", t½$, C0, and AUC4.
Applicant's summary and conclusion
- Conclusions:
- Decahydronaphthalene is rapidly eliminated by rats or mice following a single inhalation exposure. No sex differences were noted.
Therefore, no significant bioaccumulation potential is expected based on the study results. - Executive summary:
The single exposure inhalation study was designed to estimate toxicokinetic parameters relevant to the elimination
of decalin from the blood of F344/N rats and B6C3F1 mice. Male and female F344/N rats and B6C3F1 mice
received a single 6-hour whole body inhalation exposure to 25, 100, or 400 ppm decahydronaphthalene. Postexposure blood
samples were analyzed for decalin, and the results were used to estimate toxicokinetic parameters.
The half-lives for the initial elimination phase were not significantly different between sexes for rats and mice.
Differences in the terminal phase half-lives as a function of exposure concentration were also not significant
between sexes for rats or mice. At each decalin exposure concentration, no significant differences in the initial or
terminal half-lives as a function of sex for either species was observed. Half-lives for the initial elimination phase
were approximately 1.1 to 6.0 times shorter in mice than those in rats. Half-lives for the terminal elimination
phase in mice were approximately 3.4 to 5.4 times shorter than those in rats.
There are several conclusions that can be drawn from the PBPK model. First, it is not possible to detect any
differences in the metabolism of decalin between male and female mice in these data. There are significant
differences between male and female rats driven by the difference in kidney decalin concentrations. Second, the
model predicts a higher rate of metabolism for mice, but this metabolism pathway saturates at a lower
concentration than that in rats. Third, the model indicates that the highest dose (400 ppm) selected for the study
was at a concentration where metabolism was saturated. Finally, it is not possible to determine if the metabolism
and permeability parameters for male and female rats are the same; the only difference between the sexes were
parameters associated with the binding to alpha-2u-globulin.
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