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Diss Factsheets
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EC number: 619-566-0 | CAS number: 848301-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: no data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- IUCLID data have not undergone any evaluation by the European Commision - but due to the presence of n-hexane in the test material 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear' (up to 6%), it should be classified as "Xn; R48/20" [n-hexane (concentration >=5%) is classified in the EU as "Xn; R48/20"].
Data source
Reference
- Reference Type:
- other: IUCLID Dataset
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: procedure as detailed in paper by Halder et al.
- Deviations:
- not specified
- Principles of method if other than guideline:
- procedure as detailed in paper by Halder et al. (Halder, C.A., Warne, T. M. and Hatoum, N.S., Renal toxicity of gasoline and related petroleum naphthas in male rats. In: Advances in Modern Environmental Toxicology, Vol VII: Renal effects of petroleum hydrocarbons, Princeton Scientific, Princeton, NJ, 1984)
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Substance type: test substance 'Naphtha (petroleum), light alkylate' is a near analogue to 'Naphta (Fischer-Tropsch), light, C4-10 - branched and
linear'; it`s defined as:
'A complex combination of hydrocarbons produced by the distillation of the reaction products of isobutane with monoolefinic hydrocarbons usually ranging in carbon numbers from C3 through C5. It consists of predominantly branched chain saturated hydrocarbons having carbon numbers
predominantly in the range of C7-C10 and boiling in the range 90-160°C (194-320°F).'
--> the test substance is comparable to 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear'
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 21 d
- Frequency of treatment:
- 6h per day for 5 days per week
- No. of animals per sex per dose:
- test groups: - 1.54 mg/l: 10 male and 10 female animals
- 4.92 mg/l: 10 male and 10 female animals
- 15.31 mg/l: 10 male and 10 female animals
negative control group (no treatment): 10 male and 10 female animals - Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 15.31 mg/L air
- Sex:
- male/female
- Basis for effect level:
- other: no data
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In this study no systemic effects were found in female animals, but male animals displayed light hydrocarbon nephropathy. There was a 100% incidence of tubular dilation and necrosis at the corticomedullary junction of the kidneys in male rats for all three exposure groups. According to the guideline (Annex VI of Council Directive 67/548/EEC), "Xn; R48/20" should be applied for the test substance 'Naphtha (petroleum), light alkylate' --> 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear' should be also classified as "Xn; R48/20".
Furthermore, due to the presence of n-hexane in the test material 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear' (up to 6%) it should be classified as stated above [n-hexane (concentration >= 5%) is classified in the EU as "Xn; R48/20"].
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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