Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-566-0 | CAS number: 848301-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
'Naphtha (Fischer-Tropsch), light, C4 -10 - branched and linear' is a complex combination of hydrocarbons obtained from a feedstock derived from the catalytic hydrogenation of carbon monoxide (the Fischer-Tropsch Process), optionally followed by one or more of the following processes: hydrotreatment, hydroisomerization, hydrocracking. It consists predominately of branched and linear aliphatic hydrocarbons having carbon numbers in the range of C4-C10 and boiling in the range of approximately -3°C to 174°C (27 to 345.2°F).
There were no measured aquatic toxicity data for 'Naphtha (Fischer-Tropsch), light, C4-10 -branched and linear'. Therefore the toxicity of the representative chemical components of the substance to fish, invertebrates (Daphnia) and algae have been calculated by using QSARs for non-polar narcotics [key studies: 'Short-term toxicity to fish.001' and ‘Short-term toxicity to aquatic invertebrates.001’ and ‘Toxicity to aquatic algae and cyanobacteria.001’].
The following results were obtained by prediction [using the methods described in the report by Peter Fisk Associates (2006)]:
- the substance could be acutely toxic to algae at a loading rate of 0.55 mg/l and to fish and invertebrates at loading rates of 1.4 and 4.0
mg/l respectively
- the substance has predicted chronic NOELs of 0.12 mg/l to fish and invertebrates and 0.24 mg/l to algae
On the one hand the predictions are consistent with different Naphtha-study results, which were reported in the environmental hazard property summary review of ‘Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear’ [by Peter Fisk Associates (2006)].
From reviewing predicted toxicity data for a typical composition and comparing this with test data for related substances it was concluded that the substance:- could be acutely toxic to fish and invertebrates at a concentration in the range 1-10 mg/l and to algae at a concentration in the range 0.1-
1.0 mg/l
- could be chronically toxic to fish, invertebrates and algae at concentrations in the range 0.1-1.0 mg/l.
On the other hand the predicted results are consistent with studies from the IUCLID dataset (2000) of ‘Naphtha (petroleum), light alkylate’ (CAS 64741-66-8), which is a near analogue to 'Naphtha (Fischer-Tropsch), light, C4 -10 - branched and linear' [weight of evidence]:
1) Acute toxicity of 'Alkylate naphtha' to aquatic invertebrates; based on the missing identifier "CAS number" in the IUCLID dataset the substance identity was not clear - there are two possibilities:
a) Naphtha (petroleum), heavy alkylate [CAS No. 64741-65-7], which is defined as: 'A complex combination of hydrocarbons produced by distillation of the reaction products of isobutane with monoolefinic hydrocarbons usually ranging in carbon numbers from C3 to C5. It consists of predominantly branched chain saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 150°C to 220°C (302°F to 428°F).' --> test substance is slightly comparable to 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear'.
b) Naphtha (petroleum), light alkylate [CAS No. 64741-66-8], which is defined as: 'A complex combination of hydrocarbons produced by distillation of the reaction products of isobutane with monoolefinic hydrocarbons usually ranging in carbon numbers from C3 through C5. It consists of predominantly branched chain saturated hydrocarbons having carbon numbers predominantly in the range of C7 through C10 and boiling in the range of approximately 90°C to 160°C (194°F to 320°F).' --> test substance is comparable to 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear'.
Result: The LC50 (48h) of the test substance 'Alkylate naphtha' to aquatic invertebrates was calculated to be 2 mg/l, the NOEC (48h) was calculated to be 0.56 mg/l; the 24h- and 96h-LC50 values were 7.9 and 4.2 mg/l respectively [weight of evidence: ‘Short-term toxicity to aquatic invertebrates.002’].
2) Acute toxicity of ‘Naphtha (petroleum), isomerization’ [CAS No. 64741-70-4] to aquatic invertebrates; it is defined as: 'A complex combination of hydrocarbons obtained from catalytic isomerization of straight chain paraffinic C4 through C6 hydrocarbons. It consists predominantly of saturated hydrocarbons such as isobutane, isopentane, 2,2-dimethylbutane, 2-methylpentane, and 3-methylpentane' --> the test substance is slightly comparable to 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear'.
Result: The EL50 (48h) of the test substance 'Naphtha (petroleum), isomerization' to aquatic invertebrates was calculated to be 10 mg/l with a 95% confidence interval of 13 to 18 mg/l. The NOEL (48h) was calculated to be 5.0 mg/l, but the observed value was 0.5 mg/l [weight of evidence: ‘Short-term toxicity to aquatic invertebrates.003’].
3) Toxicity of ‘Alkylate naphtha’ to aquatic plants e.g. algae; based on the missing identifier "CAS number" in the IUCLID dataset the substance identity was not clear - probably the test substance has the CAS No. 64741-70-4 and is defined as: 'A complex combination of hydrocarbons obtained from catalytic isomerization of straight chain paraffinic C4 through C6 hydrocarbons. It consists predominantly of saturated hydrocarbons such as isobutane, isopentane, 2,2-dimethylbutane, 2-methylpentane, and 3-methylpentane.' --> the test substance is slightly comparable to 'Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear'.
Result:The NOEC (72h) of the test substance 'Naphtha (petroleum), isomerization' to aquatic algae was calculated to be 0.1 mg/l and the EC50 (72h) was calculated to be 13 mg/l) [weight of evidence: ‘Toxicity to aquatic algae and cyanobacteria.002’].
Conclusion:The read across data suggest that the predicted aquatic toxicity of the substance 'Naphtha (Fischer-Tropsch), light, C4 -10 - branched and linear' by Peter Fisk Associates seems to be correct. It should be noted that the original study reports have not been reviewed.
Classification: The substance 'Naphtha (Fischer-Tropsch), light, C4 -10 - branched and linear' should be classified in the EU as R50- 53 ' Very toxic to aquatic organisms' and 'May cause long-term adverse effects in the aquatic environment'. The basis of this classification is the predicted EL50 of 0,55 mg/l to algae and the presence of components with log Kow >3. The biodegradability does not affect this.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.