Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-453-8 | CAS number: 3900-45-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Weight of evidence
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The physico-chemical parameters as well as the bio-concentration factors can provide reliable indiactions on the toxico-kinetic behavior of a chemical & if the chemical shall have a tendency to bio-accumulate.
Data source
Reference
- Reference Type:
- other: Weight of evidence
- Title:
- Toxicokinetics
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters exhibited by the chemical.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(6-methoxy-2-naphthyl)ethan-1-one
- EC Number:
- 223-453-8
- EC Name:
- 1-(6-methoxy-2-naphthyl)ethan-1-one
- Cas Number:
- 3900-45-6
- Molecular formula:
- C13H12O2
- IUPAC Name:
- 1-(6-methoxynaphthalen-2-yl)ethan-1-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: unspecified
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Based on the weight of evidence of various phys chem and bioaccumulative parameters exhibited by the chemical.
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Not applicable
- Duration and frequency of treatment / exposure:
- Not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not applicable
- No. of animals per sex per dose / concentration:
- Not applicable
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
- Statistics:
- Not applicable
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The dermal absorption capacity of 1-(6-methoxy-2-naphthyl)ethan-1-one is low considering the fact that a value of 0.00300 mg/cm2/event has been predicted (Danish (Q)SAR Database Report). The particle size distribution (granulometry) of 1-(6-methoxy-2-naphthyl)ethan-1-one by the sieve analysis method was found to be in the range of 500 micrometer to 1000 micrometer. Thus, chances of absorption of inhalable particles is also low.
- Details on distribution in tissues:
- The solubility of the chemical 1-(6-methoxy-2-naphthyl)ethan-1-one is less in water compared to that in organic solvents. Hence any absorbed chemical is likely to be distributed more in the lipid fraction than in the blood.
- Details on excretion:
- Data available for similar chemicals like benzophenone indicates that bio-accumulation potential is unlikely. Thus, it can be concluded that any absorbed chemical shall be excreted out of the living system since no bio-accumulation is reported. This fact is further corroborated by the bio-concentration factor (BCF) of 1-(6-methoxy-2-naphthyl)ethan-1-one which ranges from 5 to 10. THis is much less than the threshold value of 2000 to suggest bio-accumulation.
Metabolite characterisation studies
- Details on metabolites:
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: No bio-accumulation is expected based upon the physico-chemical propoerties and BCF values of the chemical.
Based upon the physico-chemical parameters and bio-concentration factro (BCF) value of 1-(6-methoxy-2-naphthyl)ethan-1-one that ranges from 5 to 10, it can be concluded that the chemical shall not have bio-accumulation potential. - Executive summary:
Based upon the physico-chemical parameters and bio-concentration factro (BCF) value of 1-(6-methoxy-2-naphthyl)ethan-1-one that ranges from 5 to 10, it can be concluded that the chemical shall not have bio-accumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
