Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-453-8 | CAS number: 3900-45-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The estimated lethal dose concentration (LC50) of 1-(6-methoxy-2-naphthyl)ethan-1-one for daphnia magna for 24 hours using QSAR toolbox version 2.3 is 23.43 mg/l. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance it can be concluded that the substance 1-(6-methoxy-2-naphthyl)ethan-1-one is not toxic to as aquatic invertebrate daphnia magna.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 23.43 mg/L
Additional information
Based on the various studies available with Klimish rating 2 and 4 for target chemical CAS NO 3900-45-6 and the read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
LC50 |
23.43862 mg/l |
mortality |
24 hrs |
Daphnia magna |
Predicted data for target chemical |
2 |
EC50 |
44.11281 mg/L.
|
mortality |
48 hrs |
Daphnia magna |
Predicted data for target chemical |
3 |
LC50 |
15.76 mg/L.
|
mortality |
48 hrs |
Daphnia longispina |
Data is from DEPA |
4 |
LC50 |
82 mg/L.
|
mortality |
48 hrs |
Daphnia longispina |
Data from publication for CAS no 22204-53-1 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 15.76 to 82 mg/l and EC50 value was found to be44.11281 mg/l in a 48 hrs study on the basis of mortality effect. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.
Thus considering the CLP Criteria for aquatic classification of the substance it is concluded that the substance 1-(6-methoxy-2-naphthyl) ethan-1-one is not toxic to aquatic invertebrate (Daphnia magna, Daphnia longispina).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
