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EC number: 414-490-2 | CAS number: 154212-59-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 April - 19 August, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterized
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 414-490-2
- EC Name:
- -
- Cas Number:
- 154212-59-6
- Molecular formula:
- C11H9ClN2O5S
- IUPAC Name:
- 4-nitrophenyl (1,3-thiazol-5-yl)methyl carbonate hydrochloride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Seven adult males, 2- 3kg (10 - 15weeks) were allowed to acclimatise for 13 days before treatment. Six animals were used in the study.
100 - 130g/day of Certified High Fibre Rabbit Chow was provided and water was available ad libitum.
The temperature was maintained at 64 - 68°F.
The room was on a 12 hour daily light cycle.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other: right eye of each animal was untreated
- Amount / concentration applied:
- 0.05gram
- Duration of treatment / exposure:
- 0.05g test material was placed in the conjunctival sac of the left eye by gently pulling the lower eye lid away from the eyeball. The upper and lower eyelid were held closed for about one second after treatment to prevent loss of material and then released. The right eye was left untreated to serve as the control.
- Observation period (in vivo):
- Assessment of ocular damage/irritation was made approximately 1 hour and 24, 48 and 72 hours following treatment. Additional observations were performed on day 4, 7, 14 and 21. After the 24hr observation period was completed, the eyes of all rabbits were washed with lukewarm water.
- Number of animals or in vitro replicates:
- 6 male rabbits
- Details on study design:
- Before treatment both eyes were checked for sign of ocular irritation or defect with the aid of a direct light source. Only animals free of ocular damage were used in the study.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 0-21 days
- Score:
- 1.1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days, value at end of observation period 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 0-21 days
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days, value at end of observation period 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 0-21 days
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days, value at end of observation period 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 0-21 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Other effects:
- Grade 4 corneal opacity with extreme (grade 4) conjunctival
irritation persisted in 2/6 animals at the 21-day scoring.
The opacity had cleared in the remaining 4 animals by day 21
and the conjunctival irritation had recovered or was
recovering as well.
Any other information on results incl. tables
Abbott-87439 hydrochloride caused severe occular damage in the eys of rabbits in these studies including severe chemosis in all rabbits and severe corneal opacity in 3 rabbits, with opaque corneas being observed in 2 of the rabbits including corneal ulceration in one of two rabbits on the final observation day (day 21).
Comments: |
Applicant's summary and conclusion
- Interpretation of results:
- other: Severe ocular damage
- Conclusions:
- Severe occular damage was observed including severe chemosis in all rabbits. Severe corneal opacity in three rabbits was observed with opaque corneas in two of the rabbits. This includes corneal ulceration in one of the rabbits on the final day of observation (day 21)
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