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EC number: 473-730-4 | CAS number: 928768-73-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- Primary Eye IrritationICorrosion in Rabbits
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: according to EC Directive 92/69/EEC and Regulation EC/440/2008 guideline methods under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 473-730-4
- EC Name:
- -
- Cas Number:
- 928768-73-4
- Molecular formula:
- C13H28SO3
- IUPAC Name:
- 1-Octanol reaction products with epichlorhydrin and 2-mercaptoethanol
- Test material form:
- liquid: viscous
- Details on test material:
- Lot/batch #19381-92
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- New Zealand White rabbits were received from Millbrook Breeding Labs, Amherst, MA on 10/27/04 and equilibrated for at least five days. Only animals in apparent good health were made available for study assignment. Prior to being selected for this study, both eyes of each animal were examined according to the Draize technique for any evidence of irritation or abnormalities of the cornea, iris andlor conjunctiva.
A Mini-Maglite flashlight equipped with a high intensity bulb was used to aid in the examination. Three rabbits (males), free from evidence of ocular irritation or abnormalities, were assigned to this study without conscious bias.
The animals were born the week of 08/08/04. The pretest body weight range was 2.4 - 2.7 kg. The animals were identified by cage notation and a uniquely numbered metal eartag. The animals were housed 1/cage in suspended cages. Bedding was placed beneath the cages and changed at least three
times/week. Fresh PMI Rabbit Chow (Diet #5321) was provided daily. Water was available ad libitum.
The animal room, reserved exclusively for rabbits on acute tests, was temperature controlled, had a 12
hour lightidark cycle and was kept clean and vermin free.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- One eye of each rabbit was dosed. The contralateral eye served as a control. The test article (0.1 ml) was placed by syringe into the conjunctival sac which was formed by gently pulling the lower eyelid away from the eye. After instillation, the lids were held together for approximately one second to insure adequate distribution of the test article.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- three males
- Details on study design:
- Initially, one healthy New Zealand White rabbit (male), free from evidence of ocular irritation and corneal abnormalities, was dosed with the test substance.
The test
article (0.1 ml) was placed into the conjunctival sac of one eye. Based on the reactions of the initial animal, two additional animals (males) were added to the study and dosed in the same manner. The eyes were examined and scored by the Draize technique at 1, 24, 48 and 72 hours and on day 7 postdose in all animals and again on day 14 in the additional two animals. Sodium fluorescein dye procedures were used at the 24, 48 and 72 hour and day 7 observation intervals and again on day 14.
The primary eye irritation score for each rabbit, each day, was calculated.
Body weights were recorded pretest.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 59
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- 14 d
- Score:
- 0
- Max. score:
- 55
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- 14 d
- Score:
- 0
- Max. score:
- 55
- Reversibility:
- fully reversible
Any other information on results incl. tables
Corneal opacity, iritis and conjunctival irritation, noted in 3/3 eyes, cleared by day 7 in the initial animal and by day 14 in the additional animals. There were no abnormal physical signs noted during the observation period.
There were no abnormal physical signs noted during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: ocular irritant, but not corrosive
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- The tested substance is an ocular irritant, but not corrosive.
- Executive summary:
The tested substance is an ocular irritant, but not corrosive.
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