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EC number: 232-087-8
CAS number: 7785-70-8
Table 1: Body weight and weight gain in grams
Note: †: Rf2493 and Rf2537 found dead on D1
The acute oral toxicity of the test item was tested in accordance
with OECD Test Guideline 423, following GLP. 6 female Sprague-Dawley
rats divided in 2 groups were administered sequentially with test item
by oral gavage. The first set of 3 female rats was given a single
dose of 2000 mg/kg body weight. One mortality was observed after 24 h of
treatment, so the second set of 3 female rats was treated at the same
dose level. One mortality was also observed at this dose level and at 24
hours post dose. In surviving animals (4/6), a decrease of spontaneous
activity (4/4), Preyer’s reflex (2/4), muscle tones (4/4), righting
reflex (4/4), associated with eyes partly closed (2/4) were noted in the
first hours of the test. The animals recovered a normal activity at 24
hours post-dose. The body weight evolution of the animals remained
normal during the study. The macroscopic examination of the animals
found dead revealed a thinning of corpus (1/2) and forestomach (1/2)
with red spots (1/2), while the animals which survived until the end of
the study did not reveal treatment related changes. Based on these
results, the LD50 of the test item was determined to be higher
than 2000 mg/kg bw and, as per OECD Test Guideline 423, the LD50 cut-off
of the test item may be considered to be 2500 mg/kg bw.
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