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Diss Factsheets
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EC number: 469-070-1 | CAS number: 17861-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-30 - 2006-01-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L and control
- Sample storage conditions before analysis: stored in refrigerator (4 +/- 4°C) - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 1500 mg of the test item were dissolved in 15000 mL test water by intense stirring for 5 days in a closed system (to prevent evaporation of the test item from the test media) to obtain a saturated solution of the poorly water soluble test item in the test media. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Length at study initiation (length definition, mean, range and SD): 5.22 +/- 0.19 cm
- Weight at study initiation (mean and range, SD): 1.29 +/- 0.20 g
ACCLIMATION
- Acclimation period: for at least 12 days before the start of the test the fish were acclimated to the test temperature.
- Type and amount of food during acclimation: commercial fish diet
- Health during acclimation (any mortality observed): During the last 12 days prior to the start of the test no fish died in the fish batch and all fish were healthy.
FEEDING DURING TEST
- Frequency: no feeding - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 15 - 16°C
- pH:
- 7.7 - 8.0
- Dissolved oxygen:
- >= 8.3 mg/L
- Nominal and measured concentrations:
- - 100 mg/L (nominal)
- freshly prepared test media (0 h) collected at test start were analysed
- test item concentrations were below the limit of quantification (0.2 mg test item/L), no further samples were analysed - Details on test conditions:
- TEST SYSTEM
- Test vessel: 18 L glass aquaria with 15 L test medium
- Aeration: slightly aerated
- Renewal rate of test solution (frequency/flow rate): renewal every 24h
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
OTHER TEST CONDITIONS
- Photoperiod: 16h light: 8h dark
- Light intensity: 460 - 620 lux - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality and no symptoms of intoxication could be observed in the control and the test concentration (nominal 100 mg/L).
- Sublethal observations / clinical signs:
Table 1: Mortality and Symptomes of Intoxication
Nominal concentration
[mg/L]Exposure time [h]
(dead fish/ fish with symptoms)2 24 48 72 96 control 0/0 0/0 0/0 0/0 0/0 100 0/0 0/0 0/0 0/0 0/0 Table 2: pH- values in the Test media
pH Nominal concentration
[mg/L]Exposure time [h] 2 24 48 72 96 new old new old new old new old control 8.0 7.8 7.9 7.8 7.9 7.8 7.8 7.9 100 7.9 7.8 7.9 7.8 7.9 7.7 7.9 7.9 Table 3: Dissolved Oxygene Concentrations in the Test Media
Dissolved Oxygen [mg/L] Nominal concentration
[mg/L]Exposure time [h] 2 24 48 72 96 new old new old new old new old control 8.5 9.9 10.2 10.4 10.5 10.0 10.8 9.6 100 8.3 9.8 10.2 10.8 9.7 10.4 10.3 9.6 Table 4: Temperatures in the Test Media
Temperature [°C] Nominal concentration
[mg/L]Exposure time [h] 2 24 48 72 96 new old new old new old new old control 15 16 16 16 16 15 15 15 100 16 16 16 16 16 15 15 15 - Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 h LC50 to Oncorhynchus mykiss was found to be above 100 mg/L (loading rate).
Reference
Description of key information
The toxicity of 3-ethylheptamethyltrisiloxane on fish (Oncorhynchus mykiss) was determined in a GLP study according to OECD 203. No adverse effects were observed and the 96 h LC50 to Oncorhynchus mykiss was found to be above 100 mg/L (loading rate).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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