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EC number: -
CAS number: -
A reliable Local lymph node assay was performed on J-37 accoriding to
OECD Guideline 429 ((NOTOX, 2010). Three experimental groups of five
females CBA/J mice were treated with test substance concentration of 5,
10 or 25% w/w on three consecutive days, by open application on the
ears. Five vehicle control animals were similarly treated, but with
vehicle alone (Acetone/Olive(4:1 v/v)). Three days after the last
exposure, all animals were injected with 3H-methyl thymidine and after
five hours the draining (auricular lymph nodes were excised and pooled
for each animal. After precipitating the DNA of the lymph node cells,
radioactivity measurement was performed.
Mean DPM/animal values for the experimental groups treated with test
substance concentrations 5, 10, and 25% were 417, 713 and 361 DPM
respectively. The mean DPM/animal value for the vehicle control group
was 509 DPM. The SI values calculated for the substance concentrations
5, 10 and 25% were 0.8, 1.4 and 0.7 respectively. Since there was no
indication that the test substance could elicit an SI ≥3
when tested up to 25%, it was established that the EC3 value (the
estimated test substance concentration that will give a SI=3) (if any)
to DSD and CLP classification criteria for skin sensitisation, no
classification is required for J-37.
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