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Diss Factsheets
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EC number: 433-480-9 | CAS number: 623-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: official guideline method, GLP with certificate, good documentation, identity of substance clear but no details on its purity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
- Principles of method if other than guideline:
- The method was designed to comply with requirements of the Japanese Ministry of Agriculture, Forestry and Fisheries (MAFF); Testing guidlines for Toxicology Studies, 59 NohSan No. 4200, January 28 1985. Details on method: Safepharm Standard Method Number JMAFF 5
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 433-480-9
- EC Name:
- -
- Cas Number:
- 623-53-0
- Molecular formula:
- C4H8O3
- IUPAC Name:
- ethyl methyl carbonate
- Details on test material:
- Test material as stated in study report ("Sponsor's identification"): ETHYL METHYL CARBONATE
Description: colourless liquid
Date received: 02.11.1993
Storage conditions: room temperature
Container: clear glass jar
Remark of the author of this IUCLID dossier concerning the substance identity:
Every page of the copy of the study report contains an annotation referring to the data sharing agreement in place between the licensee that uses this study report and the data owner. In this data sharing agreement the identity of the chemical substance is specified with "Ethyl Methyl Carbonate - EC No. 433-480-9, CAS Nr. 623-53-0".
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Six New Zealand White rabbits were supplied by David Percival Ltd., Moston, Sandbach, Cheshire, U.K.
Weight of the animals at the start of the study: 2.47 - 2.75 kg
Age: approximately twelve to sixteen weeks
Acclimatisation period from point of delivery: minimum of 5 d
Identification of animals: yes, on inner surface of ear and cage labels, with indelible black marker-pen
Husbandry:
metal cages, each animal kept individually; drinking water and food (Spillers Rabbit Diet, Dalgety Agriculture Ltd., Almondsbury, Bristol, U.K.) ad libitum; temperature 17-20 °C, relative humidity 41-56 %; air exchange rate ca. 15 times/h; light-darkness-period: 12 h/12 h (electric lighting)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped free of fur
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL of undiluted test substance
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 1 h following the removal of the patches, and 24, 48 and 72 h later
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 0.08
- Max. score:
- 8
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: MILD IRRITANT (Draize classification scheme)
Any other information on results incl. tables
Result of examinations:
"Very slight erythema was noted at one treated skin site one hour after patch removal. Very slight erythema developed at another treated skin site at the 24-hour observation and persisted at this treated skin site at the 48-hour observation. All treated skin sites appeared normal at the 72-hour observation.
Applicant's summary and conclusion
- Interpretation of results:
- other: MILD IRRITANT
- Remarks:
- Criteria used for interpretation of results: other: as stated in study report
- Conclusions:
- In the study, ethyl methyl carbonate produced a primary irritation index of 0.08 and was classified as a MILD IRRITANT to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
To classify the test substance as Category 2: Irritant, the values for erythema/eschar and oedema have to be in the range of >=2.3 - <=4.0 (REGULATION (EC) No 1272/2008, chapter 3.2. Skin corrosion/irritation). Since the values are below that range the substance does not need to be classified as irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.