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EC number: 936-023-6 | CAS number: 950782-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA 72-3
- Deviations:
- no
- Principles of method if other than guideline:
- The afore mentioned guidelines were harmonized for various test parameters (i.e. temperature, light, etc.) to achieve optimal environmental conditions for the test organism. Scientific discretion was implemented where guideline parameters do not fully converge.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test solutions were prepared by adding the appropriate amount of stock solution (SCV120806)
to 30-L of dilution water. All test solutions with the exception of the control vessel, had a solvent load of 0.1 ml/L. This was achieved by adding additional solvent (acetone) to test solutions as needed.
- Controls: yes
- Chemical name of vehicle: Acetone
- Concentration of vehicle in test medium: 0.1 ml/L - Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sheepshead minnow
- Source: Aquatic Biosystems Inc., Fort Collins, CO
- Age at study initiation: Juvenile
- Length at study initiation: 24.9 ± 2.5 mm
- Weight at study initiation: 0.41 ± 0.15 g
ACCLIMATION
- Acclimation period: > 14 days
- Feeding Frequency: At least 3x each week. Not fed for 24 hours prior to testing.
- Food: Tetra min and brine shrimp
- Health: No mortalities during 48 hours prior to testing, no treatments for disease
- Photoperiod: 16 hours light, 8 hours dark
- Light/Dark Transition Period: 30 minutes
- Light Intensity: 50 to 100 footcandles
- Temperature: 22 ± 1.0 °C
- Salinity: 17±1‰ - Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 22 ± 1.0 °C (22.1 to 23.1 °C)
- pH:
- 7.9 to 8.1
- Dissolved oxygen:
- 5.0 to 7.7 mg/L (64 to 97% saturation)
- Salinity:
- 17 ‰
- Nominal and measured concentrations:
- Nominal Test Concentrations: Control, solvent control, 0.09, 0.19, 0.38, 0.75 and 1.50 mg a.i./L
Mean Measured Test Concentrations: Control (- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: All glass aquaria, 38-L (49.5 x 25.4 x 30.5 cm) and fill volume of 30-L (49.5 x 25.4 x 23.8 cm),
- Aeration: Yes, aeration was added on study day 2 due to declining D.O. levels. The aeration was maintained until the study ended.:
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline (Water used for estuarine organism studies and culturing in the Bayer CropScience Aquatic Toxicology Laboratory consists of artificial sea salts (HW Marinemix Professional from Hawaiian Marine Imports) mixed with blended soft water to produce a salinity of approximately 17 parts per thousand (‰).
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 629 to 720 lux (Cool white fluorescents)
EFFECT PARAMETERS MEASURED: Survival (mortality) and sublethal behavioral effects
Measurement Technique for Survival: Visual enumeration
Measurement Technique for Sublethals: Visual observations
Observation Interval: Approximately 4, 24, 48, 72 and 96 hours- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.96 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.43 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Results:
Sublethal Observations
Frequency
Nominal Test Concentration (mg a.i./L)
(maximum observed during scheduled observation events)
Control
0
Solvent Control
0
0.10
0
0.21
0
0.43
0
0.77
1
1.56
3
Mortality
Nominal Test Concentration (mg a.i./L)
Percent Dead at 96-Hours
Control
0
Solvent Control
0
0.10
0
0.21
0
0.43
0
0.77
20
1.56
100
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA 72-1
- Deviations:
- no
- Principles of method if other than guideline:
- The aforementioned guidelines were harmonized for various test parameters (i.e. temperature, light, etc.) to achieve optimal environmental conditions for the test organism. Scientific discretion was implemented where guideline parameters do not fully converge.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test solutions were prepared by adding the appropriate amount of stock solution (SOM102306)
to 45-L of soft processed water. All test solutions with the exception of the control vessel, had a
solvent load of 0.076 ml/L. This was achieved by adding additional solvent (Acetone) to test
solutions as needed.
- Controls: yes
- Chemical name of vehicle: Acetone - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Troutlodge, Inc., Sumner, WA
- Age at study initiation: Juvenile
- Length at study initiation: 51.6 ± 4.7 mm
- Weight at study initiation: 2.97 ± 0.67 g - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 50-58 mg/L CaCO2
- Test temperature:
- 12.3 to 12.5 °C
- pH:
- 7.4 to 8.0
- Dissolved oxygen:
- 6.8-10.3 mg/L
- Salinity:
- -
- Nominal and measured concentrations:
- Nominal Test Concentrations: Control, solvent control, 0.09, 0.19, 0.38, 0.75, and 1.5 mg a.i./L
Mean Measured Test Concentrations: Control (<0.003), solvent control (<0.003), 0.10, 0.19, 0.42, 0.78 and 1.46 mg a.i./L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
Test Vessel Material: All Glass
Test Vessel Size: 48-L (52.1x 30.5 x 30.5 cm)
Testing Volume: 45-L (52.1x 30.5 x 28.3 cm)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.66 g/L (grams of fish per liter test solution)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 770 to 919 lux (measured range)
EFFECT PARAMETERS MEASURED: Survival (mortality) and sublethal behavioral effects - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.572 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Test results:
Sublethal Observations
Frequency
Mean Measured Test Concentration (mg a.i./L)
(maximum observed during scheduled observation events)
Control
0
Solvent Control
0
0.10
0
0.19
0
0.42
0
0.78
0
1.46
6 Loss of Equilibrium
Mortality
Mean Measured Test Concentration (mg a.i./L)
Percent Dead at 96-Hours
Control
0
Solvent Control
10 % (one fish escaped from test aquarium. It appeared normal but was sacrificed since it was no longer in the test solution.)
0.10
0
0.19
0
0.42
0
0.78
100 %
1.46
100 %
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA 72-1
- Deviations:
- no
- Principles of method if other than guideline:
- The afore mentioned guidelines were harmonized for various test parameters (i.e. temperature, light, etc.) to achieve optimal environmental conditions for the test organism. Scientific discretion was implemented where guideline parameters do not fully converge.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test solutions were prepared by adding the appropriate amount of stock solution (SPP010708A)
to 30-L of dilution water. All test solutions with the exception of the control vessel, had a
solvent load of 0.1 ml/L.
- Controls: yes
- Chemical name of vehicle: Dimethylformamide (DMF) - Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead Minnow
- Source: Aquatic Bio Systems, Fort Collins, CO
- Age at study initiation: Juvenile
- Length at study initiation: 41.5 ± 2.6 mm
- Weight at study initiation: 0.62 ± 0.11 g
ACCLIMATION
- Acclimation period: > 14 days - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 50 to 54 mg/L CaCO2
- Test temperature:
- 22.1 to 22.8 °C
- pH:
- 7.6 to 8.1
- Dissolved oxygen:
- 7.3 to 8.4 mg/L (D. O. Saturation Range (%): 84 to 96%)
- Salinity:
- -
- Nominal and measured concentrations:
- Nominal Test Concentrations: Control, Solvent Control, 0.13, 0.26, 0.52, 1.05 and 2.09 mg a.i./L
Mean Measured Test Concentrations: Control (<0.01), Solvent Control (<0.01), 0.15, 0.27, 0.55, 1.07 and 2.19 mg a.i./L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
Test Vessel Material: All Glass
Test Vessel Size: 38-L (49.5 x 25.4 x 30.5 cm)
Testing Volume: 30-L (49.5 x 25.4 x 23.8 cm)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.21 g/L (grams of fish per liter test solution)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
- Interval for Water Quality Measurements: Daily for pH and D.O.; Day 0 and Day 4 for alkalinity, hardness, and
conductivity
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 718 to 1008 lux
EFFECT PARAMETERS MEASURED: Survival (mortality) and sublethal behavioral effects - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.77 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.27 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Test results:
Sublethal Observations
Frequency
Mean Measured Test Concentration (mg a.i./L)
(maximum observed during scheduled observation events)
Control
0
Solvent Control
0
0.15
0
0.27
0
0.55
10
1.07
10
2.19
2
Mortality
Mean Measured Test Concentration (mg a.i./L)
Percent Dead at 96-Hours
Control
0
Solvent Control
0
0.15
0
0.27
0
0.55
0
1.07
100%
2.19
100%
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU 91/414/EEC
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA 72-3
- Deviations:
- no
- Principles of method if other than guideline:
- The aforementioned guidelines were harmonized for various test parameters (i.e. temperature, light, etc.) to achieve optimal environmental conditions for the test organism. Scientific discretion was implemented where guideline parameters do not fully converge.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test solutions were prepared by adding the appropriate amount of stock solution (SLM111306)
to 34-L of dilution water. All test solutions with the exception of the control vessel, had a
solvent load of 0.1 ml/L. This was achieved by adding additional solvent (acetone) to test
solutions as needed.
- Controls: yes
- Chemical name of vehicle: Acetone - Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- TEST ORGANISM
- Common name: Bluegill
- Source: Osage Catfisheries, Osage Beach, MO, USA
- Age at study initiation: Juvenile
- Length at study initiation: 37.7 ± 2.6 mm
- Weight at study initiation: 1.32 ± 0.33 g
ACCLIMATION
- Acclimation period: > 14 days
- Acclimation conditions (same as test or not): same
- Type and amount of food: Tetramin and brine shrimp
- Feeding frequency: At least 3x each week. Not fed for 24 hours prior to testing - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 56 to 58 mg/L
- Test temperature:
- 22.0 to 22.3 °C
- pH:
- 8.0 to 8.1
- Dissolved oxygen:
- 6.6 to 8.1 mg/L (75 to 93% saturation)
- Salinity:
- -
- Nominal and measured concentrations:
- Nominal Test Concentrations: Control, Solvent Control, 0.09, 0.19, 0.38, 0.75 and 1.50 mg a.i./L
Mean Measured Test Concentrations: Control (<0.006), solvent control (<0.003), 0.10, 0.21, 0.39, 0.75 and 1.54 mg a.i./L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
Test Vessel Size: 38-L (49.5 x 25.4 x 30.5 cm)
Test Vessel Material: All glass aquaria
Test Vessel Fill Volume: 34-L (49.5 x 25.4 x 27 cm)
- Aeration: yes
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 50 - 100 footcandles, 538 to 1076 lux (Cool white fluorescents)
EFFECT PARAMETERS MEASURED: Survival (mortality) and sublethal behavioral effects
Measurement Technique for Survival: Visual enumeration
Measurement Technique for Sublethals: Visual observations
Observation Interval: Approximately 4, 24, 48, 72 and 96 hours - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.32 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.21 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Results:
Sublethal Observations
Frequency
Mean Measured Test Concentration (mg a.i./L)
(maximum observed during scheduled observation events)
Control
0
Solvent Control
0
0.10
0
0.21
0
0.39
2
0.75
0
1.54
9
Mortality
Mean Measured Test Concentration (mg a.i./L)
Percent Dead at 96-Hours
Control
0
Solvent Control
0
0.10
0
0.21
0
0.39
80
0.75
100
1.54
100
Referenceopen allclose all
Description of key information
The substance is toxic to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.32 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 0.96 mg/L
Additional information
Four short term studies with fish were performed for the evaluation of short term effects to freshwater (cold and warm water) and saltwater fish. All studies referred to herein were conducted in accordance with the prevailing OECD testing guidelines (OECD 203) and GLP. Following the evaluation of the acute toxicity studies with fish, it has been concluded that the lowest LC50 for fish is 0.32 mg/L for Lepomis macrochirus.
All short term effects of the substance towards fish were found in the same range providing a LC50 (96h) of 0.57 mg/L for the cold water rainbow trout (Oncorhynchus mykiss) and an LC50 (96h) of 0.77 mg/L for the Fathead Minnow (Pimephales promelas). The saltwater test revealed in a LC50 of 0.96 mg/L for Sheepshead Minnow (Cyprinodon variegatus).
The substance is toxic to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.