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EC number: 690-526-2 | CAS number: 38632-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- An acute inhalation toxicity test was conducted with rats to determine the potential for the aerosolized dust of 1,1' -(1 ,6-Hexanediyldiimino)bis[l-oxo-methanesulfonic acid], sodium salt (1 :2) to produce toxicity via the inhalation (nose-only exposure) route. Ten healthy rats (5/sex) were exposed to the test atmosphere og 5.57 mh/m³ for 4 hours. The animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days following exposure. Body weights were recorded prior to exposure and again on days 1, 3, 7 and 14 (termination). Necropsies were performed on all animals at terminal sacrifice.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Methansulfonic acid (1,6-hexanediyl-diimino)bis[1-oxo, disodium salt
- EC Number:
- 690-526-2
- Cas Number:
- 38632-47-2
- Molecular formula:
- C8H14S2N2O8.Na2
- IUPAC Name:
- Methansulfonic acid (1,6-hexanediyl-diimino)bis[1-oxo, disodium salt
- Details on test material:
- Test substance, identified as 1, 1' -(1 ,6-Hexanediyldiimino)bis[l-oxo-methanesulfonie acid], sodium salt (1:2)
Composition: 91.4%, Citric acid - 6.6%, Tween 20 - 2%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Gravimetric chamber concentration: 5.57 mg/L
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.57 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
All animals survived exposure to the test atmosphere. Following exposure all rats exhibited facial staining, nasal discharge and/or abnormal respiration. All animals recovered from the above symptoms by Day 2 and, apart from ocular discharge observed in one male on Days 8 and 9, appeared active and healthy for the remainder of the observation period. Although three males and two females lost or failed to gain body weight by Day 1, they showed a continued weight gain thereafter and along with all other animals gained weight through Day 14. No gross abnormalities were noted far any of the animals when necropsied at the conclusion of the 14-day observation period.
Applicant's summary and conclusion
- Executive summary:
An acute inhalation toxicity test was conducted with rats to determine the potential for the aerosolized dust of 1,1' -(1 ,6-Hexane- diyldiimino)bis[l-oxo-methanesulfonic acid], sodium salt (1 :2) to produce toxicity via the inhalation (nose-only exposure) route. Under the conditions of this study, the single exposure acute inhalation LC50 ofthe test substance is greater than 5.57 mg/L in male and fe male rats.
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