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EC number: 922-114-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EL50 (48h) = 48.39 mg/L (QSAR, read-across from hexane and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane)
NOELR (48h) = 10.82 mg/L (QSAR, read-across from hexane)
Key value for chemical safety assessment
Additional information
There are no data available on the toxicity to microorganisms of hydrocarbons, C5-C6, n-alkanes, isoalkanes, <5% n-hexane. However, there are reliable data available considered suitable for read-across using the analogue approach.
The target substance is a hydrocarbon solvent with carbon numbers in the range of C5 to C6. The main constituents of the mixed solvent consist of about 43% of C6 species and about 57% of C5 species. n-Hexane is only present in concentrations < 5% of the total volume.
Taking into account all available data, animal and human toxicity data as well as environmental fate and effects data show that source substances have a similar (eco-)toxicological and environmental fate properties as the target substance.
Therefore, read-across is performed based on an analogue approach (for details please refer to the analogue justification which is attached in section 13 of the technical dossier).
For a number of analogue substances the aquatic toxicity was estimated by a QSAR, using the Petrotox computer model (v 3.04), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients K(MW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater 48 hour EL50 and NOELR values based on growth inhibition are as follows:
Hydrocarbons, C6, isoalkanes, < 5% n-hexane: EL50 = 70.68 mg/L (Concawe 2009)
Hydrocarbons, C6, isoalkanes, < 5% n-hexane: NOELR = 15.81 mg/L (Concawe 2009)
Hexane: EL50 = 48.39 mg/L (Concawe 2009)
Hexane: NOELR = 10.82 mg/L (Concawe 2009)
Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich: EL50 = 51.84 mg/L (Concawe 2009) Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich: NOELR = 11.59 mg/L (Concawe 2009)Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich: EL50 = 48.39 mg/L (Concawe 2009)
Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich: NOELR = 11.54 mg/L (Concawe 2009)
Pentane: EL50 = 105.9 mg/L (Concawe 2009) Pentane: NOELR = 23.7 mg/L (Concawe 2009)QSARs resulted in EL50s and NOELRs in a range of 48.39 mg/L - 105.9 mg/L and 10.82 mg/L - 23.7 mg/L, respectively. As key studies the QSARs conducted for hexane and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich were chosen demonstrating the most critical EL50 with 48.39 mg/L and NOELR with 10.82 mg/L.
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