Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-581-0 | CAS number: 108-42-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Metabolites of m-chloroaniline in the urine of rats and rabbits after oral application and in the blood of dogs after intravenous injection were determined. Additionally the elimination time of m-chloroanilinefrom the body was investigated.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
In rats and rabbits the majority of ingested m-chloroaniline was eliminated within 24 hours. In dogs the majority of m-chloroaniline was eliminated from the blood within a few hours.
The leading metabolic reaction in rats is the ring hydroxylation of m-chloroaniline. The main metabolites were derivatives of 4-amino-2-chlorophenol and to a lesser part of 2-amino-4-chlorophenol. In rabbits after dosage with m-chloroaniline, the metabolites 4-amino-2-chlorophenol and 2 -amino-4 -chlorophenol (the same as in rats) were detected in the urine hydrolyzed with sulfuric acid.
In dogs m-chloronitrosobenzene and N-hydroxy-m-chloroaniline were detected as metabolites in the blood 2 hours after intravenous injection of m-chloroaniline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
