Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
reaction product of: saturated, monounsaturated and multiple unsaturated long-chained partly estrified alcohols of vegetable origin (Brassica napus L., Brassica rapa L., Helianthus annuus L., Glycine hispida, Gossypium hirsutum L., Cocos nucifera L., Elaeis guineensis) with O,O-diisobutyldithiophosphate and 2-ethylhexylamine and hydrogen peroxide
EC number: 428-630-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 29, 1992 to January 19, 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in accordance with recognised guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 428-630-5
- EC Name:
- -
- Molecular formula:
- Not applicable
- IUPAC Name:
- reaction product of Z-9-octadecen-1-ol and O,O-diisobutyl hydrogen dithiophosphate
- Details on test material:
- - Name of test material (as cited in study report): Becrosan 6920
- Physical state: clear, brown liquid
- Lot/batch No.: 395 1
- Expiration date of the lot/batch: December 3 1,1993
- Storage condition of test material: ambient
- Other:
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Han: WIST (Syn: Wistar), white
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
zentralinstitut fiir
Versuchstierzucht GmbH
Hermann-Ehlers-Allee 57
W-3OOO Hannover 91
- Age at study initiation:
- Weight at study initiation: m: 207 - 238 g, f: 156 - 187 g
- Fasting period before study: The animals were fasted from 16 h before until 3 - 4 h after administration of the test article.
- Housing: collective housing u to a maximum of 5 animals per cage (Makrolon8 t ype 111)
- Acclimation period: at least 5 days
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C to 25°C
- Humidity (%): 30 – 70%
- Photoperiod (hrs dark / hrs light): artificial lighting (120 lux) from 7.00 a.m. - 7.00 p.m.
IN-LIFE DATES: NDA
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Not applicable
- Doses:
- The test article was administered undiluted in a volume of 2.04 ml/kg, or 2000 mg/kg
- No. of animals per sex per dose:
- 5 /sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were examined at the following post-treatment intervals: 10 min, 1 h, 2 h, 6 h, 24 h, and thereafter once daily up to day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight no further details available - Statistics:
- An estimate of the acute oral median lethal dose (LD50) of the substance was made using the mortality data obtained.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0
- Clinical signs:
- other: No abnormal clinical signs were observed.
- Gross pathology:
- Gross pathological examinations at 14 days p. a. (terminal necropsy) revealed no test articledependent findings. Those macroscopic changes observed were attributable to the sacrificing procedure or to minor variations which can occur spontaneously in rats of this strain and age.
- Other findings:
- - Organ weights: No Data Available
- Histopathology: No Data Available
- Potential target organs: No Data Available
- Other observations:No Data Available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the requirements of the limit test, the LD50 values after 24 h and 14 days were as follows: male and female > 2000 mgkg
- Executive summary:
INTRODUCTION AND AIM
The aim of the test was to determine the acute median lethal dose of "Becrosan 6920". Information derived from this test serves to indicate the existence of possible hazards likely to arise from short-term exposure to the test article by the oral route.
The test was conducted according to the OECD guideline for the testing of chemicals OECD 401 (February 24, 1987) and the EEC directive 84/49 EEC (September 19, 1984). The study was carried out as described in the corresponding protocol approved by the testing facility and the study sponsor on November 25 and 30, 1992, respectively. The principles of Good Laboratory Practice for the testing of chemicals as specified by national (BGB1. I, no. 13,Q 19 a, March 22, 1990) and international (OECD, Paris, 1982) legislation were followed during the performance of the study.
SUMMARY
The acute oral toxicity of"Becrosan 6920"was investigated in 5 male and 5 female Wistar rats.
On the basis of the range finding results, the animals were given a single oral administration of"Becrosan 6920"at a dose of 2000 mg/kg.
Clinical observations were conducted at regular intervals during the 14-day observation period. Gross pathological examinations were performed on all animals 14 days p.a.
Body weights were measured at days 0,7and 14 days p.a.
The following results were obtained:
1. No abnormal clinical signs were observed.
2. Weight gains were normal in all animals.
3. Gross pathological examinations at 14 days p.a. (terminal necropsy) revealed no test article -dependent findings.
4. According to the requirements of the limit test, the LD50 values after 24 h and 14 days were as follows: male and female > 2000mgkg
5. The above value is higher than the limit specified as harmful by the EEC directive
91/325/EEC and the Gefahrstoffverordnung (GefStoffV), 1987 (BGBl. I, p. 2721).
When administered by the oral route, the test article "Becrosan 6920” may therefore be classified as "non-toxic".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.