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reaction product of: saturated, monounsaturated and multiple unsaturated long-chained partly estrified alcohols of vegetable origin (Brassica napus L., Brassica rapa L., Helianthus annuus L., Glycine hispida, Gossypium hirsutum L., Cocos nucifera L., Elaeis guineensis) with O,O-diisobutyldithiophosphate and 2-ethylhexylamine and hydrogen peroxide
EC number: 428-630-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 27/1998 to Jan 31/1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in compliance with agreed test protocols following guidance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 428-630-5
- EC Name:
- -
- Molecular formula:
- Not applicable
- IUPAC Name:
- reaction product of Z-9-octadecen-1-ol and O,O-diisobutyl hydrogen dithiophosphate
- Test material form:
- other: liquid
- Details on test material:
- - Substance type: orange-yellow, clear liquid
- Physical state: orange-yellow, clear liquid
- Lot/batch No.: 12447
- Storage condition of test material: in a well closed container and protected from light at room temperature
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
None.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The amount of the test substance dissolved in water was checked by DOC analysis (Dissolved Organic Carbon) made at the beginning of the test, after 48 hours and after 96 hours. Samples taken fkom each test vessel were centrifkged at 3,500 rpm for 10 minutes in order to separate the substance unsolved. The concentration of DOC in the clear aqueous phase was determined.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The nominal concentration of the test group was 100 mg/l. 400 mg test substance and 4L test water were stirred for 24 hours. The mixture of water and test substance were used for the test
- Eluate: reconstituted water (Potassium chloride 5.75 mg/l; Calcium chloride Dihydrate 294.00 mg/l; Magnesium sulphate Heptahydrate 123.25 mg/l; and Sodium bicarbonate 64.75mg/l).
- Differential loading: not applicable.
- Controls: test medium.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no information is available.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Source: Labor- und Zierfischzuchtbetrieb Gunter Rosenhainer
- Age at study initiation (mean and range, SD): no data
- Length at study termination (length definition, mean, range and SD): 2.6 - 3.5 cm
- Weight at study termination (mean and range, SD): no data
ACCLIMATION
- Acclimation period: 12 days
- Acclimation conditions (same as test or not): yes
- Type and amount of food: fiozen larvae of mosquitoes
- Feeding frequency: daily and discontinued 24 hours prior to the test period
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- none
- Test temperature:
- 2 1.8-22.4 deg C
- pH:
- 7.4-7.9
- Dissolved oxygen:
- 8.0 - 8.5 mg O2/L.
- Salinity:
- not applicable.
- Nominal and measured concentrations:
- nominal concentrations: 0 and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Type (delete if not applicable): static
- Aeration: at least 8.6 mg/l; the vessels were aerated
- No. of organisms: 1 fish /Liter
- Biomass loading rate: 0.39 g bw/L
OTHER TEST CONDITIONS
- Adjustment of pH: no data
- Photoperiod: 15 hours light, 9 hours dark
- Light intensity: no data
TEST CONCENTRATIONS
- Range finding study: none.
- Test concentrations: 0 and 100 mg/L - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- There were no mortalities in fish exposed to a 100 mg/l test substance for a period of 96 hours.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- None.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 1: Cumulative mortality data in the definitive study.
Conc. (mg/L)
Cumulative mortality
% mortality
0 h
24 h
48 h
72 h
96 h
96 h
Control
0
0
0
0
0
0
100
0
0
0
0
0
0
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-Hour LC50 zebrafish based on nominal concentration was greater than 100 mg/L.
- Executive summary:
Introduction:A study was performed to assess the acute toxicity of the test material to Zebra-fish (Brachydanio rerio). The method followed that described in the guideline 92/69/EEC, part C. 1.
Methods:Zebra fish was exposed to the test material, at a single nominal concentration of 100 mg/L for a period of 96 hours under static test conditions. The number of mortalities and any sub-lethal effects of exposure in test and control vessel were determined 6 hours after the start of exposure and then daily throughout the study until termination after 96 hours.
The dissolved oxygen concentration, pH values and temperature were checked daily.
Results:
The concentration of the substance in test water was measured by determination of the Dissolved Organic Carbon (DOC). At the start of the test the concentration was 3.8 mg/l and at the end of the exposure period the value was 4.5 mg/l.
No mortalities occurred during the test in the control and the test group. The fish showed no visible abnormalities. The 96-Hour LC50 based on nominal concentration was greater than 100 mg/L. It was considered unnecessary and unrealistic to test at loading rates in excess of 100 mg/L. The substance is not acute toxic to fish.
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