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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from WHO report on chlorophenols (collective views of an international group of experts).
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Chlorophenols other than pentachlorphenol (environmental health criteria 93)
- Author:
- EHC
- Year:
- 1 989
- Bibliographic source:
- http://www.inchem.org
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3,7,8-Tetrachlorooxanthrene (2,3,7,8-tetrachlorodibenzo-p-dioxin) / 1746-01-6
- IUPAC Name:
- 2,3,7,8-Tetrachlorooxanthrene (2,3,7,8-tetrachlorodibenzo-p-dioxin) / 1746-01-6
- Reference substance name:
- 2,4,5-trichlorophenol / 95-95-4
- IUPAC Name:
- 2,4,5-trichlorophenol / 95-95-4
- Reference substance name:
- 2,3,4,6-TETRACHLOROPHENOL / 12698-64-5
- IUPAC Name:
- 2,3,4,6-TETRACHLOROPHENOL / 12698-64-5
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Any other information on results incl. tables
Effects on Man
Occupational exposure
Worker exposure is a major concern in industries in which chlorophenols are used extensively, as respiratory and dermal absorption of these compounds results in measurable levels in the blood and urine of exposed workers.
In the manufacture of chlorophenols, clinical symptoms associated with exposure include eye, nose, and airway irritation, dermatitis, chloracne, and porphyria. Abnormal liver function tests, changes in brain wave activity, and slowed visual reaction time have been reported in association with high-level exposure.
In sawmill workers, Na-tetrachlorophenol exposures have caused numerous cases of dermatitis and respiratory irritation. Eye, nose, and airway irritation from exposure to trichlorophenols have been reported by gas mask testers.
Cancer incidence and mortality to chlorophenol
Conflicting results have come from epidemiological studies relating cancer incidence and mortality to chlorophenol exposure in the work place. Associations between soft-tissue sarcoma, malignant lymphoma, and nasal and nasopharyngeal cancer, have been shown in some epidemiological studies, but not in others. Exposure levels have not been accurately determined in these studies, and the conflicting results remain unresolved, at present.
Non-occupational exposure (additional information)
Low (usually 10 mg/kg) levels of the lower chlorinated phenols are found in the serum, urine, and adipose tissues of the general population. The major identifiable sources of these chlorophenols are food and drinking-water. Chlorophenol levels in the ambient atmosphere have not been measured.
In the only instance of acute exposure of the general population to chlorophenols, an explosion at a manufacturing plant contaminated an area, with a population of 37 000 persons, with sodium hydroxide, 2,4,5-trichlorophenol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, the effects, if any, of the released 2,4,5-trichlorophenol were masked by those of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Clinical symptoms attributed to 2,3,7,8-tetrachlorodibenzo-p-dioxin were recorded in the exposed individuals. No toxic effects have been attributed to the low concentrations of chlorophenols typical of most non-occupational exposures. However, undesirable organoleptic effects are produced by chlorophenols at very low concentrations.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.