6-Chlorohexanoic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Only brief testing condition was described in this reference.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

H.F.Symth,Jr., C.P.Carpenter, C.S.Weil, U.C.Pozzani, J.A. Striegel

Year:

1962

Bibliographic source:

American Industry Hygiene Association Journal, vol. 23, 95 - 107 pages (19629

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted male rats.
The dosages are arranged in a logarithmic series differing by differing by a factor of two.
Based on the mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the table of Weil.

GLP compliance:

not specified

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

6-Chlorohexanoic acid

EC Number:

700-529-3

Cas Number:

4224-62-8

Molecular formula:

C6H11ClO2

IUPAC Name:

6-Chlorohexanoic acid

Details on test material:

Information such as purity, compositions and so on, is not availabe in this reference.

Test animals

Species:

rat

Strain:

other: Carworth-Wister rat

Sex:

male

Details on test animals or test system and environmental conditions:

Test animals

Source: Lockland
age: four to five weeks
Weight: 90 - 120 grams
Habituation: rats were reared in their colony and maintained from time of weaning.
Fasting: none

Enviromental conditions:
No data

Administration / exposure

Route of administration:

other: Gastirc intubation

Vehicle:

not specified

Details on oral exposure:

Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted male rats.

Doses:

No data

No. of animals per sex per dose:

male five per dose

Control animals:

not specified

Details on study design:

Single oral dose toxicity is estimated by the gastric intubation of rats.
Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range is estimated by the method of Thompson using the Table of Weil.

Statistics:

Thompson's method; Use of moving averages and interpolation to estimate median effective Dose. (ref. W.R. Thompson, Bacteriol. Rev., 11, 115 (1947)
Table of Weil; Table for convenient calculation of median-effective dose (LD50 or ED50), ref. Biometrics, vol. 8, 249 (1952)

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

3 080 mg/kg bw

95% CL:

> 2.49 - < 3.81

Applicant's summary and conclusion

Interpretation of results:

relatively harmless

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 on acute oral toxicity of this substance is reported as 3080 mg/kg for male rat.
This value corresponds to " not classified" for CLP regulation, so we concluded oral toxicity of this substance is "relatively harmless".